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. 2023 May;25(5):616-631.
doi: 10.1002/ejhf.2848. Epub 2023 Apr 26.

Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society

Hiroyuki Tsutsui  1 , Nancy M Albert  2 , Andrew J S Coats  3 , Stefan D Anker  4   5 , Antoni Bayes-Genis  6   7 , Javed Butler  8   9 , Ovidiu Chioncel  10 , Christopher R Defilippi  11 , Mark H Drazner  12 , G Michael Felker  13 , Gerasimos Filippatos  14 , Mona Fiuzat  13 , Tomomi Ide  1 , James L Januzzi Jr  15 , Koichiro Kinugawa  16 , Koichiro Kuwahara  17 , Yuya Matsue  18 , Robert J Mentz  13   19 , Marco Metra  20 , Ambarish Pandey  21 , Giuseppe Rosano  22 , Yoshihiko Saito  23   24 , Yasushi Sakata  25 , Naoki Sato  26 , Petar M Seferovic  27 , John Teerlink  28 , Kazuhiro Yamamoto  29 , Michihiro Yoshimura  30
Affiliations
Free article

Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society

Hiroyuki Tsutsui et al. Eur J Heart Fail. 2023 May.
Free article

Abstract

Natriuretic peptides, brain (B-type) natriuretic peptide (BNP) and N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are globally and most often used for the diagnosis of heart failure (HF). In addition, they can have an important complementary role in the risk stratification of its prognosis. Since the development of angiotensin receptor-neprilysin inhibitors (ARNIs), the use of natriuretic peptides as therapeutic agents has grown in importance. The present document is the result of the Trilateral Cooperation Project among the Heart Failure Association of the European Society of Cardiology, the Heart Failure Society of America and the Japanese Heart Failure Society. It represents an expert consensus that aims to provide a comprehensive, up-to-date perspective on natriuretic peptides in the diagnosis and management of HF, with a focus on the following main issues: (1) history and basic research: discovery, production and cardiovascular protection; (2) diagnostic and prognostic biomarkers: acute HF, chronic HF, inclusion/endpoint in clinical trials, and natriuretic peptide-guided therapy; (3) therapeutic use: nesiritide (BNP), carperitide (ANP) and ARNIs; and (4) gaps in knowledge and future directions.

Keywords: Diagnosis; Heart failure; Natriuretic peptides; Therapy.

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