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Review
. 2023 Jul;27(14):1923-1927.
doi: 10.1111/jcmm.17754. Epub 2023 Apr 26.

Vitamin D may alleviate pre-eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature

Cui-Ping Li  1 , Hua-Qin Su  2 , Lian-Ping He  1
Affiliations
Review

Vitamin D may alleviate pre-eclampsia by modulating the ferroptosis signalling pathway: A hypothesis based on recent literature

Cui-Ping Li et al. J Cell Mol Med. 2023 Jul.

Abstract

Ferroptosis is a novel form of regulated cell death typically characterized by non-apoptotic, iron-dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis plays an important role in the pathophysiology of pre-eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets.

Keywords: ferroptosis; pre-eclampsia; signalling pathways.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Classification of hypertension in pregnancy.
FIGURE 2
FIGURE 2
Signalling pathways implicated in ferroptosis.
See this image and copyright information in PMC

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