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Review
. 2023 Apr 17:2023:6210885.
doi: 10.1155/2023/6210885. eCollection 2023.

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration

Zhangfu Li  1 , Honghao Yang  1 , Yong Hai  1 , Yunzhong Cheng  1
Affiliations
Review

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration

Zhangfu Li et al. Mediators Inflamm. .

Abstract

Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Diagram of IDD upstream and downstream regulation networks.
Figure 2
Figure 2
Schematic illustration of different cells expressing various cytokines.
Figure 3
Figure 3
IL-1α and IL-1β synthesis and signal transduction pathways.
Figure 4
Figure 4
IL-1β is involved in multiple pathological processes of intervertebral disc degeneration.
Figure 5
Figure 5
TNF-α signalling pathway.
Figure 6
Figure 6
The role of ROS/oxidative stress in the development of IDD.
See this image and copyright information in PMC

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