Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 21:10:436-440.
doi: 10.1016/j.toxrep.2023.02.008. eCollection 2023.

Xanthomicrol: Effective therapy for cancer treatment

Neda Poormolaie  1 , Mohammad Mohammadi  2 , Amirabbas Mir  3 , Mehrdad Asadi  4 , Alireza Nouhi Kararoudi  5 , Vahid Vahedian  6   7 , Mohsen Rashidi  8   9 , Nazila Fathi Maroufi  6
Affiliations
Review

Xanthomicrol: Effective therapy for cancer treatment

Neda Poormolaie et al. Toxicol Rep. .

Abstract

Cancer treatment is one of the main challenges of global health. For decades, researchers have been trying to find anti-cancer compounds with minimal side effects. In recent years, flavonoids, as a group of polyphenolic compounds, have attracted the attention of researchers due to their beneficial effects on health. Xanthomicrol is one of the flavonoids that has the ability to inhibit growth, proliferation, survival and cell invasion and ultimately tumor progression. Xanthomicrol, as active anti-cancer compounds, can be effective in the prevention and treatment of cancer. Therefore, the use of flavonoids can be suggested as a treatment along with other medicinal agents. It is obvious that additional investigations in cellular levels and animal models are still needed. In this review article, the effects of xanthomicrol on various cancers have been reviewed.

Keywords: Apoptosis; Cancer; Treatment; Xanthomicrol.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

ga1
Graphical abstract
Fig. 1
Fig. 1
Chemical structure of xanthomicrol.
Fig. 2
Fig. 2
Effects of xanthomicrol on breast cancer apoptosis and angiogenesis.
See this image and copyright information in PMC

References

    1. Pourmohammad P., et al. Potential therapeutic effects of melatonin mediate via miRNAs in cancer. Biochem. Genet. 2021;60:1–23. - PubMed
    1. Hajipour H., et al. Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers. Artif. Cells Nanomed., Biotechnol. 2018;46(sup1):283–292. - PubMed
    1. Maroufi N.F., et al. The apatinib inhibits breast cancer cell line MDA-MB-231 in vitro by inducing apoptosis, cell cycle arrest, and regulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Breast Cancer. 2020;27(4):613–620. - PubMed
    1. Mohammadian J., et al. Formulation of Stattic as STAT3 inhibitor in nanostructured lipid carriers (NLCs) enhances efficacy of doxorubicin in melanoma cancer cells. Naunyn-Schmiede 'S. Arch. Pharmacol. 2020;393(12):2315–2323. - PubMed
    1. Talib W.H., et al. Melatonin in cancer treatment: current knowledge and future opportunities. Molecules. 2021;26(9):2506. - PMC - PubMed

LinkOut - more resources