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. 2023 May-Jun;37(3):1164-1172.
doi: 10.21873/invivo.13191.

Cutaneous Melanoma of the Lip: A SEER Analysis of Epidemiology and Survival Outcomes With Focus on Surgery and Other Treatment Options

Juan A Viscardi  1 , Matteo Scampa  1 , Solange N Walz  1 , Jerome Martineau  1 , Pietro G DI Summa  2 , Salvatore Giordano  3 , Daniel F Kalbermatten  1 , Carlo M Oranges  4
Affiliations

Cutaneous Melanoma of the Lip: A SEER Analysis of Epidemiology and Survival Outcomes With Focus on Surgery and Other Treatment Options

Juan A Viscardi et al. In Vivo. 2023 May-Jun.

Abstract

Background/aim: Cutaneous melanoma of the lip (LM) is a rare malignancy with a low overall survival (OS). Few studies exist in the literature to aid its diagnosis and treatment. The purpose of this study was to assess the different treatment modalities by collecting cases from a single database and to provide current information on the epidemiologic characteristics of cutaneous lip melanoma.

Patients and methods: The SEER database was searched for demographic, clinical-pathological, and therapeutic characteristics. The Kaplan-Meier model was used to analyze the overall survival (OS) of the study population, and survival curves were modelled. Univariable analysis between subgroups was carried out using the log-rank test. Surgery was further assessed with a multivariable cox regression, where the surgical procedure was adjusted for Breslow thickness.

Results: Patients aged 62.4 years on average, and 62.7% of them were males. A total of 386 melanomas of the cutaneous lip were identified. Mean OS was 155.1 months, median OS was 187 months, and 67.4% had localized disease.

Conclusion: LM has a poor prognosis with a 5-year OS of 75.2%. Surgery remains the mainstay of treatment, with less invasive surgical approaches yielding a comparable overall survival to surgery with greater margins.

Keywords: Melanoma; SEER; epidemiology; lip; malignant; skin; survival; treatment.

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Conflict of interest statement

The Authors declare no conflicts of interest in relation to this study.

Figures

Figure 1
Figure 1. Overall survival curves, according to age, gender, and stage at diagnosis.
Figure 2
Figure 2. Overall survival curves, according to radiotherapy, surgical procedure, and chemotherapy.
Figure 3
Figure 3. Overall survival curves, according to Breslow thickness, ulceration, histologic subtype, and mitotic rate.
See this image and copyright information in PMC

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