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. 2023 Jul-Aug;49(4):928-939.
doi: 10.1002/biof.1955. Epub 2023 Apr 27.

Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho-associated kinase pathway

Fatma H Rizk  1 , Mervat H El-Saka  1 , Rowida Raafat Ibrahim  2 , Omnia Safwat El-Deeb  2 , Hoda A Ibrahim  2 , Amira A El Saadany  3 , Shaimaa S Mashal  4 , Leila Ammar  5 , Amal M Abdelsattar  6 , Ramez A Barhoma  1
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Possible mitigating effect of adropin on lung injury in diabetic rats: Targeting the role of Rho A/Rho-associated kinase pathway

Fatma H Rizk et al. Biofactors. 2023 Jul-Aug.

Abstract

This study evaluated possible mitigating effect of adropin on lung injury in diabetic rats, targeting role of Rho A/Rho-associated kinase pathway. Rats were allocated into four groups: control, adropin, diabetic, and diabetic+adropin groups. At the termination of the experiment, serum fasting glucose, insulin and adropin levels and insulin resistance were calculated. Wet/dry ratio, histopathological, immunohistochemical analyses, and relative real time gene expression of lung tissue was determined. Interleukin-6, tumor necrosis factor alpha, malondialdehyde, 8-Oxo-2'-deoxyguanosine, reduced glutathione, superoxide dismutase, Bcl-2, BAX, myeloperoxidase, intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and transforming growth factor-β were determined in lung tissue. Adropin treatment in diabetic rats notably attenuated hyperglycemia and insulin resistance. Also, it mitigated diabetic lung injury via suppressing effect on Rho A/ROCK pathway, apoptosis, inflammatory reactions, oxidative stress, and fibrosis of lung tissue. Adropin can be considered as a promising therapeutic agent for treating diabetic lung injury.

Keywords: Rho A/ROCK pathway; adropin; diabetic; hyperglycemia; lung injury.

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