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. 2023 Aug;43(6):1137-1138.
doi: 10.1007/s10875-023-01490-y. Epub 2023 Apr 27.

Case of Fatal Meningitis in an Adult Patient with IRAK4 Deficiency

Nisha Verma  1 , Susan Tadros  2 , Sameer Bahal  2 , David M Lowe  2   3 , Siobhan O Burns  2   3
Affiliations

Case of Fatal Meningitis in an Adult Patient with IRAK4 Deficiency

Nisha Verma et al. J Clin Immunol. 2023 Aug.
No abstract available

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Conflict of interest statement

D.M.L has received personal fees from Gilead for an educational video on COVID-19 in immunodeficiency, from Merck for a roundtable discussion on risk of COVID-19 in immunosuppressed patients, speaker fees from Biotest and support to attend a conference from Octapharma. D.M.L.’s institution has received consultancy fees from GSK and has received research grants from GSK, Bristol Myers Squibb, National Institute for Health and Care Research, UK Medical Research Council and LifeArc, all outside the current work.

All other authors declare no competing interests.

References

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    1. Ku C-L, von Bernuth H, Picard C, Zhang S-Y, Chang H-H, Yang K, et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007;204:2407–2422. doi: 10.1084/jem.20070628. - DOI - PMC - PubMed
    1. McDonald DR, Brown D, Bonilla FA, Geha RS. Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol. 2006;118:1357–1362. doi: 10.1016/j.jaci.2006.08.006. - DOI - PubMed
    1. Picard C, Puel A, Bonnet M, Ku C-L, Bustamante J, Yang K, et al. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science. 2003;299:2076–2079. doi: 10.1126/science.1081902. - DOI - PubMed
    1. Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, et al. IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens. Blood. 2014;124:3561–3571. doi: 10.1182/blood-2014-07-587824. - DOI - PMC - PubMed

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