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Editorial
. 2023 Apr 1;4(4):e434-e436.
doi: 10.34067/KID.0000000000000105.

Predicting Responses to Hypertonic Saline: Edelman's Evidence, Elementary Algebra, and Eponyms

Richard H Sterns  1 , Adam M Sterns
Affiliations
Editorial

Predicting Responses to Hypertonic Saline: Edelman's Evidence, Elementary Algebra, and Eponyms

Richard H Sterns et al. Kidney360. .
No abstract available

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Figures

Figure 1
Figure 1
Changes in serum Na+ concentration predicted by Na+, K+, and fluid balance. (A) Linear regression of observed versus predicted change in plasma water cation concentration. Modified from the figure in a 1957 study by Wynn et al. TBW was measured in each participant at baseline with antipyrine or tritium and was then determined 24 hours later by remeasurement (n=10) or from the change in body weight (n=3). Baseline body cation content equals baseline plasma cation concentration multiplied by baseline TBW. Body cation content at 24 hours equals baseline cation content plus measured cation balance (Na+ and K+ intake minus output). Predicted plasma cation concentration at 24 hours equals body cation content at 24 hours divided by TBW at 24 hours. (B) Linear regression of Δ (Na+e+K+e)/TBW to Δ plasma sodium concentration. Modified from Figure 1 in the 1958 study by Edelman et al. Serial measurements of Na+e+K+e and TBW measured isotopically were obtained in 15 patients as described in the text.
See this image and copyright information in PMC

Comment on

References

    1. Edelman IS, Leibman J, O'meara MP, Birkenfeld LW. Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest. 1958;37(9):1236–1256. doi:10.1172/jci103712 - DOI - PMC - PubMed
    1. Wynn V. The osmotic behaviour of the body cells in man: significance of changes of plasma-electrolyte levels in body-fluid disorders. Lancet. 1957;270(7007):1212–1218. doi:10.1016/s0140-6736(57)90177-0 - DOI - PubMed
    1. Wagner B Malhotra D Schmidt D, et al. . Hypertonic saline infusion for hyponatremia: limitations of the Adrogué-Madias and other formulas. Kidney360. 2023;4(4):555–561. Publish Ahead of Print. doi:10.34067/KID.0000000000000075 - DOI - PMC - PubMed
    1. Rose BD. New approach to disturbances in the plasma sodium concentration. Am J Med. 1986;81(6):1033–1040. doi:10.1016/0002-9343(86)90401-8 - DOI - PubMed
    1. Adrogue HJ, Madias NE. Aiding fluid prescription for the dysnatremias. Intensive Care Med. 1997;23(3):309–316. doi:10.1007/s001340050333 - DOI - PubMed

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