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. 2023 Jun 1;46(6):1265-1270.
doi: 10.2337/dc22-2440.

The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results

RADIANT Study Group
Collaborators

The Rare and Atypical Diabetes Network (RADIANT) Study: Design and Early Results

RADIANT Study Group. Diabetes Care. .

Abstract

Objective: The Rare and Atypical Diabetes Network (RADIANT) will perform a study of individuals and, if deemed informative, a study of their family members with uncharacterized forms of diabetes.

Research design and methods: The protocol includes genomic (whole-genome [WGS], RNA, and mitochondrial sequencing), phenotypic (vital signs, biometric measurements, questionnaires, and photography), metabolomics, and metabolic assessments.

Results: Among 122 with WGS results of 878 enrolled individuals, a likely pathogenic variant in a known diabetes monogenic gene was found in 3 (2.5%), and six new monogenic variants have been identified in the SMAD5, PTPMT1, INS, NFKB1, IGF1R, and PAX6 genes. Frequent phenotypic clusters are lean type 2 diabetes, autoantibody-negative and insulin-deficient diabetes, lipodystrophic diabetes, and new forms of possible monogenic or oligogenic diabetes.

Conclusions: The analyses will lead to improved means of atypical diabetes identification. Genetic sequencing can identify new variants, and metabolomics and transcriptomics analysis can identify novel mechanisms and biomarkers for atypical disease.

Trial registration: ClinicalTrials.gov NCT05544266.

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Conflict of interest statement

Duality of Interest. No potential conflicts of interest relevant to this article were reported.

Figures

None
Graphical abstract
Figure 1
Figure 1
RADIANT protocol flow. OGTT, oral glucose tolerance test; RNA-Seq, RNA sequencing; KPD, ketosis-prone diabetes; LD, lipodystrophy.
Figure 2
Figure 2
Consolidated Standards of Reporting Trials (CONSORT) diagram: stage 1.
Figure 3
Figure 3
Consolidated Standards of Reporting Trials (CONSORT) diagram: stage 2. DCC, Data Coordination Center, University of South Florida; RNA-Seq, RNA sequencing.
Figure 4
Figure 4
Consolidated Standards of Reporting Trials (CONSORT) diagram: stage 3. Boxes with dashed lines represent additional recommended testing that has not started as yet. OGTT, oral glucose tolerance test.
See this image and copyright information in PMC

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