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. 2023 Apr 27;33(1):17.
doi: 10.1038/s41533-023-00338-7.

Asthma control among treated US asthma patients in Practice Fusion's electronic medical record research database

Jonathan Davitte  1 , Bailey DeBarmore  2 , David Hinds  2 , Shiyuan Zhang  3 , Jessica Chao  1 , Leah Sansbury  2
Affiliations

Asthma control among treated US asthma patients in Practice Fusion's electronic medical record research database

Jonathan Davitte et al. NPJ Prim Care Respir Med. .

Abstract

This study investigated burden of 'not well-controlled' asthma, overall and by Global Initiative for Asthma (GINA) Step, among treated asthma patients in Practice Fusion's research database. Asthma control (Asthma Control Test [ACT]) was stratified by GINA Step; prevalence ratios were estimated using Poisson regression with robust variance controlled for confounders. ACT scores ≤19 reflect not well-controlled; >19 reflect 'well-controlled' asthma. Of 15,579 patients, 30% had not well-controlled asthma at index date. The proportion of patients with not well-controlled asthma increased from GINA Step 1 (29%) to Step 5 (45%). Compared with Step 1, the proportion of patients with not well-controlled asthma was 0.87-times lower in Step 2, 1.10-times greater in Step 4, and 1.37-times greater in Step 5. Results suggest that despite available treatments, patients remain symptomatic across GINA Steps in real-world primary care and specialist outpatient practices, with incremental disease burden and unmet medical need in these populations.

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Conflict of interest statement

J.D., S.Z., J.C., D.H., L.S., B.D. declare no competing non-financial interests but the following competing financial interests: J.D., S.Z., and J.C. are employees of GSK and hold stocks/shares in GSK; D.H. and L.S. were employees of GSK and held stocks and shares at the time of the study; B.D. is a Ph.D candidate at UNC Chapel Hill and works as a research assistant at GSK.

Figures

Fig. 1
Fig. 1. Study design.
ACT asthma control test; Chronic obstructive pulmonary disease.
Fig. 2
Fig. 2. Construction of study sample.
Inclusion and exclusion criteria applied to construct the final study sample. ACT asthma control test, COPD chronic obstructive pulmonary disease, GINA Global Initiative for Asthma.
Fig. 3
Fig. 3. Asthma control status of patients by GINA Step at index date.
Percentage and number of individuals with ‘Not well-controlled’ and ‘Well-controlled’ asthma. GINA Global Initiative for Asthma.
Fig. 4
Fig. 4. Association between GINA Step and asthma control at index date.
Adjusted prevalence ratio of ‘Not well-controlled’ asthma by GINA Step among the treated asthma population. CI confidence interval, GINA Global Initiative for asthma, PR prevalence ratio.
See this image and copyright information in PMC

References

    1. Global Initiative for Asthma. Global strategy for asthma management and prevention 2021https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V... (Global Initiative for Asthma, 2021).
    1. Centers for Disease Control and Prevention & U.S. Department of Health & Human Services. National Health Interview Survey Data 2019, https://www.cdc.gov/asthma/nhis/2019/table3-1.htm (Centers for Disease Control and Prevention & U.S. Department of Health & Human Services, 2019).
    1. Taylor DR, et al. A new perspective on concepts of asthma severity and control. Eur. Respir. J. 2008;32:545–554. doi: 10.1183/09031936.00155307. - DOI - PubMed
    1. González-Freire B, Vázquez I, Pértega-Díaz S. The relationship of psychological factors and asthma control to health-related quality of life. J Allergy Clin. Immunol. Pract. 2020;8:197–207. doi: 10.1016/j.jaip.2019.07.009. - DOI - PubMed
    1. Woodcock A, et al. P39 The salford lung study in asthma: relationship between asthma control test (ACT) control status and future asthma exacerbations. Thorax. 2018;73:A117–A118.

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