Global trends in research related to the links between microbiota and antibiotics: a visualization study

Abstract

The scientific community widely acknowledges that the gut microbiota plays a critical role in maintaining host health and can be altered by a range of factors, such as antibiotic use, diet, stress, and infections. Therefore, this study utilized bibliometric analysis to thoroughly investigate research trends in the microbiota and antibiotics. Scopus was used to extract papers linked to microbiota and antibiotics published between 2002 and 2021, and both Microsoft Excel and VOSviewer were used to conduct the analysis of the data. A total of 2,816 publications discussed the connection between the microbiota and antibiotics. Growth occurred in two stages: the first (2002-2015) was characterized by fairly slow publication production, while the second (2016-2021) saw a rapid increase in publishing progress. The United States has the most publications, 654, representing 23.22% of the total. China came second with 372 publications (13.21%), followed by the United Kingdom with 161 publications (5.72%) and India with 157 publications (5.58%). In addition, publications on 'altered intestinal microbiota composition with antibiotic treatment' were introduced after 2017, while 'gut microbiota and antimicrobial resistance' and 'probiotics as an alternative antimicrobial therapy' were introduced before 2017. Based on these results, this study provides an in-depth look at key moments in the history of microbiota and antibiotic research, as well as possible directions for future research in different areas of microbiota and antibiotic research. Therefore, it is suggested that more attention should be given to the latest promising hotspots, such as how antibiotic treatment changes the composition of the gut microbiota.

Figure 1

Trends in publications for research on the microbiota and antibiotics between 2002 and 2021.

Figure 2

International (cross-country) research collaboration between countries with a minimum contribution of 30 articles. There were 27 countries on the map.

Figure 3

Research topics clustered by mapping the cooccurrences of terms for publications on microbiota and antibiotics. Of the 49,251 terms, 111 terms occurred at least 100 times.

Figure 4

Overlay visualization map of the time sequence of frequently used terms in the microbiota and antibiotics (2002–2021). Yellow terms represent the most recent research.