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Review
. 2023 Apr 1;12(4):691.
doi: 10.3390/antibiotics12040691.

Candida lipolytica Bloodstream Infection in an Adult Patient with COVID-19 and Alcohol Use Disorder: A Unique Case and a Systematic Review of the Literature

Omar Simonetti  1 , Verena Zerbato  1 , Sara Sincovich  1 , Lavinia Cosimi  1 , Francesca Zorat  2 , Venera Costantino  3 , Manuela Di Santolo  3 , Marina Busetti  3 , Stefano Di Bella  4 , Luigi Principe  5 , Roberto Luzzati  4
Affiliations
Review

Candida lipolytica Bloodstream Infection in an Adult Patient with COVID-19 and Alcohol Use Disorder: A Unique Case and a Systematic Review of the Literature

Omar Simonetti et al. Antibiotics (Basel). .

Abstract

Candida lipolytica is an uncommon Candida species causing invasive fungemia. This yeast is mainly associated with the colonisation of intravascular catheters, complicated intra-abdominal infections, and infections in the paediatric population. Here, we report a case of C. lipolytica bloodstream infection in a 53-year-old man. He was admitted for an alcohol withdrawal syndrome and mild COVID-19. Among the primary risk factors for candidemia, only the use of broad-spectrum antimicrobials was reported. The empiric treatment was commenced with caspofungin and then targeted with intravenous fluconazole. Infective endocarditis was ruled out using echocardiography, and PET/TC was negative for other deep-seated foci of fungal infection. The patient was discharged after blood culture clearance and clinical healing. To the best of our knowledge, this is the first case of C. lipolytica candidemia in a patient with COVID-19 and alcohol use disorder. We performed a systematic review of bloodstream infections caused by C. lipolytica. Clinicians should be aware of the possibility of C. lipolytica bloodstream infections in patients with alcohol use disorder, especially in a COVID-19 setting.

Keywords: COVID-19; Candida lipolytica; Yarrowia lipolytica; alcohol use disorder; candidemia; caspofungin; fluconazole; fungemia.

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Conflict of interest statement

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
C. lipolytica colonies (arrow) growing on Sabouraud agar.
Figure 2
Figure 2
Literature search strategy.
See this image and copyright information in PMC

References

    1. Pappas P.G., Kauffman C.A., Andes D.R., Clancy C.J., Marr K.A., Ostrosky-Zeichner L., Reboli A.C., Schuster M.G., Vazquez J.A., Walsh T.J., et al. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin. Infect. Dis. 2016;62:e1–e50. doi: 10.1093/cid/civ933. - DOI - PMC - PubMed
    1. Falagas M.E., Roussos N., Vardakas K.Z. Relative Frequency of Albicans and the Various Non-Albicans Candida Spp among Candidemia Isolates from Inpatients in Various Parts of the World: A Systematic Review. Int. J. Infect. Dis. 2010;14:e954–e966. doi: 10.1016/j.ijid.2010.04.006. - DOI - PubMed
    1. Liu W.-C., Chan M.-C., Lin T.-Y., Hsu C.-H., Chiu S.-K. Candida Lipolytica Candidemia as a Rare Infectious Complication of Acute Pancreatitis: A Case Report and Literature Review. J. Microbiol. Immunol. Infect. 2013;46:393–396. doi: 10.1016/j.jmii.2013.04.007. - DOI - PubMed
    1. Kim E.J., Lee E., Kwak Y.G., Yoo H.M., Choi J.Y., Kim S.R., Shin M.J., Yoo S.-Y., Cho N.-H., Choi Y.H. Trends in the Epidemiology of Candidemia in Intensive Care Units from 2006 to 2017: Results from the Korean National Healthcare-Associated Infections Surveillance System. Front. Med. 2020;7:606976. doi: 10.3389/fmed.2020.606976. - DOI - PMC - PubMed
    1. Machado M., Estévez A., Sánchez-Carrillo C., Guinea J., Escribano P., Alonso R., Valerio M., Padilla B., Bouza E., Muñoz P. Incidence of Candidemia Is Higher in COVID-19 versus Non-COVID-19 Patients, but Not Driven by Intrahospital Transmission. J. Fungi. 2022;8:305. doi: 10.3390/jof8030305. - DOI - PMC - PubMed

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