Endophthalmitis in Silicone Oil-Filled Eyes

doi:10.3390/antibiotics12040736

Review

. 2023 Apr 10;12(4):736.

doi: 10.3390/antibiotics12040736.

Endophthalmitis in Silicone Oil-Filled Eyes

Magdalene Yin Lin Ting¹, Soyang Ella Kim¹, Rodrigo Anguita^{1

2}

Affiliations

¹ Moorfields Eye Hospital NHS Foundation Trust, City Road, London EC1V 2PD, UK.
² Department of Ophthalmology, Inselspital, University Hospital of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.

PMID: 37107098
PMCID: PMC10135016
DOI: 10.3390/antibiotics12040736

Review

Endophthalmitis in Silicone Oil-Filled Eyes

Magdalene Yin Lin Ting et al. Antibiotics (Basel). 2023.

. 2023 Apr 10;12(4):736.

doi: 10.3390/antibiotics12040736.

Authors

Magdalene Yin Lin Ting¹, Soyang Ella Kim¹, Rodrigo Anguita^{1

2}

Affiliations

¹ Moorfields Eye Hospital NHS Foundation Trust, City Road, London EC1V 2PD, UK.
² Department of Ophthalmology, Inselspital, University Hospital of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.

PMID: 37107098
PMCID: PMC10135016
DOI: 10.3390/antibiotics12040736

Abstract

Incidences of post pars plana vitrectomy (PPV) endophthalmitis vary between 0.02% and 0.13%, and infectious endophthalmitis in silicone oil-filled eyes is even rarer. We performed a literature review to describe the incidence, protective and predisposing factors, causative pathogens, management options, and prognosis of infectious endophthalmitis in silicone oil-filled eyes. Various studies have elucidated different aspects of this condition. Causative pathogens commonly include commensals. Traditional management involves the removal of silicone oil (SO), intravitreal antibiotics and then SO re-injection. Alternatively, injecting intravitreal antibiotics into silicone oil-filled eyes has also been reported. Visual prognoses are uniformly guarded. Due to the uncommon nature of this condition, studies are limited either by their retrospective design or by small sample sizes. However, observational studies, case series, and case reports can play an important role in rare conditions until larger studies are conducted. This comprehensive review aims to summarise the information available in the literature, to act as a good source for ophthalmologists looking for answers on this topic, and to suggest areas for future development.

Keywords: anti-microbial properties; infectious endophthalmitis; pars plana vitrectomy; silicone oil.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Cohen S.M., Flynn H.W., Murray T.G., Smiddy W.E., Avins L.R., Blodi C.F., Chang S., Cohen S.M., Elner S.G., Flynn H.W., et al. Endophthalmitis after Pars Plana Vitrectomy. Ophthalmology. 1995;102:705–712. doi: 10.1016/S0161-6420(95)30965-7. - DOI - PubMed
1. Okonkwo O.N., Hassan A.O., Oderinlo O., Gyasi M.E. Burkholderia Cepacia, a Cause of Post Pars Plana Vitrectomy Silicone Oil Related Endophthalmitis: Clinico-Pathological Presentation and Outcome of Management. Int. J. Retin. Vitr. 2018;4:35. doi: 10.1186/s40942-018-0138-7. - DOI - PMC - PubMed
1. Sinisi F., Della Santina M., Loiudice P., Figus M., Casini G. The Role of Silicone Oil in the Surgical Management of Endophthalmitis: A Systematic Review. J. Clin. Med. 2022;11:5445. doi: 10.3390/jcm11185445. - DOI - PMC - PubMed
1. Clarke B., Williamson T.H., Gini G., Gupta B. Management of Bacterial Postoperative Endophthalmitis and the Role of Vitrectomy. Surv. Ophthalmol. 2018;63:677–693. doi: 10.1016/j.survophthal.2018.02.003. - DOI - PubMed
1. Du D.T., Wagoner A., Barone S.B., Zinderman C.E., Kelman J.A., MaCurdy T.E., Forshee R.A., Worrall C.M., Izurieta H.S. Incidence of Endophthalmitis after Corneal Transplant or Cataract Surgery in a Medicare Population. Ophthalmology. 2014;121:290–298. doi: 10.1016/j.ophtha.2013.07.016. - DOI - PubMed

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[1] Cohen S.M., Flynn H.W., Murray T.G., Smiddy W.E., Avins L.R., Blodi C.F., Chang S., Cohen S.M., Elner S.G., Flynn H.W., et al. Endophthalmitis after Pars Plana Vitrectomy. Ophthalmology. 1995;102:705–712. doi: 10.1016/S0161-6420(95)30965-7. - DOI - PubMed

[2] Cohen S.M., Flynn H.W., Murray T.G., Smiddy W.E., Avins L.R., Blodi C.F., Chang S., Cohen S.M., Elner S.G., Flynn H.W., et al. Endophthalmitis after Pars Plana Vitrectomy. Ophthalmology. 1995;102:705–712. doi: 10.1016/S0161-6420(95)30965-7. - DOI - PubMed

[3] Okonkwo O.N., Hassan A.O., Oderinlo O., Gyasi M.E. Burkholderia Cepacia, a Cause of Post Pars Plana Vitrectomy Silicone Oil Related Endophthalmitis: Clinico-Pathological Presentation and Outcome of Management. Int. J. Retin. Vitr. 2018;4:35. doi: 10.1186/s40942-018-0138-7. - DOI - PMC - PubMed

[4] Okonkwo O.N., Hassan A.O., Oderinlo O., Gyasi M.E. Burkholderia Cepacia, a Cause of Post Pars Plana Vitrectomy Silicone Oil Related Endophthalmitis: Clinico-Pathological Presentation and Outcome of Management. Int. J. Retin. Vitr. 2018;4:35. doi: 10.1186/s40942-018-0138-7. - DOI - PMC - PubMed

[5] Sinisi F., Della Santina M., Loiudice P., Figus M., Casini G. The Role of Silicone Oil in the Surgical Management of Endophthalmitis: A Systematic Review. J. Clin. Med. 2022;11:5445. doi: 10.3390/jcm11185445. - DOI - PMC - PubMed

[6] Sinisi F., Della Santina M., Loiudice P., Figus M., Casini G. The Role of Silicone Oil in the Surgical Management of Endophthalmitis: A Systematic Review. J. Clin. Med. 2022;11:5445. doi: 10.3390/jcm11185445. - DOI - PMC - PubMed

[7] Clarke B., Williamson T.H., Gini G., Gupta B. Management of Bacterial Postoperative Endophthalmitis and the Role of Vitrectomy. Surv. Ophthalmol. 2018;63:677–693. doi: 10.1016/j.survophthal.2018.02.003. - DOI - PubMed

[8] Clarke B., Williamson T.H., Gini G., Gupta B. Management of Bacterial Postoperative Endophthalmitis and the Role of Vitrectomy. Surv. Ophthalmol. 2018;63:677–693. doi: 10.1016/j.survophthal.2018.02.003. - DOI - PubMed

[9] Du D.T., Wagoner A., Barone S.B., Zinderman C.E., Kelman J.A., MaCurdy T.E., Forshee R.A., Worrall C.M., Izurieta H.S. Incidence of Endophthalmitis after Corneal Transplant or Cataract Surgery in a Medicare Population. Ophthalmology. 2014;121:290–298. doi: 10.1016/j.ophtha.2013.07.016. - DOI - PubMed

[10] Du D.T., Wagoner A., Barone S.B., Zinderman C.E., Kelman J.A., MaCurdy T.E., Forshee R.A., Worrall C.M., Izurieta H.S. Incidence of Endophthalmitis after Corneal Transplant or Cataract Surgery in a Medicare Population. Ophthalmology. 2014;121:290–298. doi: 10.1016/j.ophtha.2013.07.016. - DOI - PubMed

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Endophthalmitis in Silicone Oil-Filled Eyes

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Endophthalmitis in Silicone Oil-Filled Eyes

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