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Review
. 2023 Apr 10;24(8):6978.
doi: 10.3390/ijms24086978.

The Pathogenesis of Diabetes

Huiqin Guo  1 , Haili Wu  2 , Zhuoyu Li  1
Affiliations
Review

The Pathogenesis of Diabetes

Huiqin Guo et al. Int J Mol Sci. .

Abstract

Diabetes is the most common metabolic disorder, with an extremely serious effect on health systems worldwide. It has become a severe, chronic, non-communicable disease after cardio-cerebrovascular diseases. Currently, 90% of diabetic patients suffer from type 2 diabetes. Hyperglycemia is the main hallmark of diabetes. The function of pancreatic cells gradually declines before the onset of clinical hyperglycemia. Understanding the molecular processes involved in the development of diabetes can provide clinical care with much-needed updates. This review provides the current global state of diabetes, the mechanisms involved in glucose homeostasis and diabetic insulin resistance, and the long-chain non-coding RNA (lncRNA) associated with diabetes.

Keywords: diabetes; hyperglycemia; insulin resistance; long-chain non-coding RNA (lncRNAs); signal pathway.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Signaling mechanisms in regulating glucose metabolism.
Figure 2
Figure 2
LncRNAs are closely associated with the development of diabetic complications.
See this image and copyright information in PMC

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