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. 2023 Apr 10;24(8):7026.
doi: 10.3390/ijms24087026.

Microbiome Composition in Microscopic Colitis: A Systematic Review

Aleksandra Garczyk  1 , Marcin Mardas  2 , Marta Stelmach-Mardas  1
Affiliations

Microbiome Composition in Microscopic Colitis: A Systematic Review

Aleksandra Garczyk et al. Int J Mol Sci. .

Abstract

Believed to be a rare cause of chronic diarrhoea, microscopic colitis (MC) is a condition with rising incidence. Many prevalent risk factors and the unknown pathogenesis of MC rationalise the need for studies on microbiota composition. PubMed, Scopus, Web of Science and Embase were searched. Eight case-control studies were included. The risk of bias was assessed with the Newcastle-Ottawa Scale. Clinical details on the study population and MC were poor. The most consistent result among the studies was a decreased Akkermansia genus in faecal samples. Other results were inconsistent due to the different taxonomic levels of the outcomes. Possible changes in different taxa were observed in patients who suffered from MC compared to healthy controls. The alpha diversity compared between MC and the diarrhoea control may suggest potential similarities. The beta diversity in MC compared to healthy and diarrhoeal populations showed no significant outcomes. The microbiome composition in MC possibly differed from the healthy control, but no agreement regarding taxa was made. It might be relevant to focus on possible factors influencing the microbiome composition and its relationship with other diarrhoeal diseases.

Keywords: collagenous colitis; intestinal flora; lymphocytic colitis; microbiome; microbiota; microscopic colitis; systematic review.

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Conflict of interest statement

There is no conflict of interest to declare.

Figures

Figure 1
Figure 1
Flow diagram regarding microbiome-related studies.
See this image and copyright information in PMC

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