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. 2023 Apr 14;13(4):1014.
doi: 10.3390/life13041014.

HIV-Indicator Condition Guided Testing in a Hospital Setting

Diletta Barbanotti  1 , Camilla Tincati  1 , Alessandro Tavelli  1 , Andrea Santoro  1 , Matteo Sala  1 , Teresa Bini  1 , Anna De Bona  1 , Antonella d'Arminio Monforte  1 , Giulia Carla Marchetti  1
Affiliations

HIV-Indicator Condition Guided Testing in a Hospital Setting

Diletta Barbanotti et al. Life (Basel). .

Abstract

Late diagnosis is still a major issue in HIV infection management, leading to important consequences for both patients and community. In this perspective, HIV screening targeted on some clinical conditions (HIV indicator conditions-HIVICs) emerged as a useful strategy, also involving patients not considered at high behavioral risk. We organized an in-hospital HIVICs guided screening campaign named ICEBERG in Milan, Italy, between 2019 and 2021. Among the 520 subjects enrolled, mainly presenting with viral hepatitis or mononucleosis-like syndrome, 20 resulted HIV positive (3.8% prevalence). A significant proportion of them had multiple conditions and advanced immunosuppression, with 40% being AIDS-presenters. As adherence to the screening campaign was modest for non-ID specialists, educational interventions to raise clinicians' sensitivity are urgently needed. HIV-ICs guided testing was confirmed as a useful tool, but a combined approach with other screening strategies seems to be essential for early HIV diagnosis.

Keywords: AIDS; HIV; HIV indicator conditions; late diagnosis; screening.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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