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Review
. 2023 Apr 16;13(4):1026.
doi: 10.3390/life13041026.

The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease

N M Liyanage  1 , D P Nagahawatta  1 , Thilina U Jayawardena  2 , You-Jin Jeon  1   3
Affiliations
Review

The Role of Seaweed Polysaccharides in Gastrointestinal Health: Protective Effect against Inflammatory Bowel Disease

N M Liyanage et al. Life (Basel). .

Abstract

Inflammatory bowel disease (IBD) is a prominent global public health issue. Anti-inflammatory medications, immunosuppressants, and biological therapies are currently used as treatments. However, they are often unsuccessful and have negative consequences on human health. Thus, there is a tremendous demand for using natural substances, such as seaweed polysaccharides, to treat IBD's main pathologic treatment targets. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae, and fucoidan in brown algae. These are effective candidates for drug development and functional nutrition products. Algal polysaccharides treat IBD through therapeutic targets, including inflammatory cytokines, adhesion molecules, intestinal epithelial cells, and intestinal microflora. This study aimed to systematically review the potential therapeutic effects of algal polysaccharides on IBD while providing the theoretical basis for a nutritional preventive mechanism for IBD and the restoration of intestinal health. The results suggest that algal polysaccharides have significant potential in complementary IBD therapy and further research is needed for fully understanding their mechanisms of action and potential clinical applications.

Keywords: gastrointestinal health; inflammatory bowel disease; polysaccharide; seaweed.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Lesions appear during Crohn’s disease (CD) and ulcerative colitis (UC). (a) CD lesion involving entire digestive tract and (b) UC lesion located in large intestine and rectum.
Figure 2
Figure 2
Key contributing factors to IBD.
See this image and copyright information in PMC

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