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Review
. 2023 Mar 28;11(4):859.
doi: 10.3390/microorganisms11040859.

Bacterial Infection in the Sickle Cell Population: Development and Enabling Factors

Lucrèce M Délicat-Loembet  1   2 , Mohamed Ag Baraïka  3   4 , Flabou Bougoudogo  4   5 , Dapa A Diallo  3
Affiliations
Review

Bacterial Infection in the Sickle Cell Population: Development and Enabling Factors

Lucrèce M Délicat-Loembet et al. Microorganisms. .

Abstract

The high frequency of bacterial infections represents a major threat to public health. In developing countries, they are still responsible for significant morbidity and mortality in pediatric populations with sickle cell disease, particularly in children under 5 years of age. Indeed, they have an increased susceptibility to bacterial infections due to their immune deficiency. This susceptibility is even greater for pneumococcal and salmonella infections. In addition, the underdevelopment of some countries and socio-economic factors increases this condition. This review examines the common and specific factors leading to infections in people with sickle cell disease in different types of developed and undeveloped countries. The threat of bacterial infections, particularly those caused by S. pneumoniae and Salmonella, is of increasing concern due to the rise in bacterial resistance to antibiotics. In light of this disturbing data, new strategies to control and prevent these infections are needed. Solutions could be systematic penicillin therapy, vaccinations, and probabilistic antibiotic therapy protocols.

Keywords: bacterial infections; risk factors; sickle cell anemia.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Modell B., Darlison M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull. World Health Organ. 2008:480–487. doi: 10.2471/BLT.06.036673. - DOI - PMC - PubMed
    1. Labie D., Elion J. The problem of sickle cell disease in Africa. Med. Trop. Rev. Du Corps De Sante Colonial. 2010;70:449–453. - PubMed
    1. Diagne I., Diagne-Gueye N.R., Signate-Sy H., Camara B., Lopez-Sall P.H., Diack-Mbaye A. Prise en charge de la drepanocytose chez l’enfant en Afrique: Experience de la cohorte de l’hopital d’enfants Albert Royer de Dakar. Med. Trop. 2003;63:513–520. - PubMed
    1. McGann P.T., Grosse S.D., Santos B., de Oliveira V., Bernardino L., Kassebaum N.J., Ware R.E., Airewele G.E. A Cost-Effectiveness Analysis of a Pilot Neonatal Screening Program for Sickle Cell Anemia in the Republic of Angola. J. Pediatr. 2015;167:1314–1319. doi: 10.1016/j.jpeds.2015.08.068. - DOI - PMC - PubMed
    1. Hau I., Coïc L. L’enfant drépanocytaire aux urgences. Med. Ther. Pediatr. 2008;11:35–42.

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