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Review
. 2023 Apr 10;28(8):3354.
doi: 10.3390/molecules28083354.

A Comprehensive Survey on the Expediated Anti-COVID-19 Options Enabled by Metal Complexes-Tasks and Trials

Judy Gopal  1 , Manikandan Muthu  1 , Iyyakkannu Sivanesan  2
Affiliations
Review

A Comprehensive Survey on the Expediated Anti-COVID-19 Options Enabled by Metal Complexes-Tasks and Trials

Judy Gopal et al. Molecules. .

Abstract

Contemporary pharmacology dating back to the late 19th/early 20th centuries has benefitted largely from the incorporation of metal complexes. Various biological attributes have been successfully realized using metal/metal complex-based drugs. Among anticancer, antimicrobial, and antiviral applications, anticancer applications have extracted the maximum benefit from the metal complex, Cisplatin. The following review has compiled the various antiviral benefits harnessed through inputs from metal complexes. As a result of exploiting the pharmacological aspects of metal complexes, the anti-COVID-19 deliverables have been summarized. The challenges ahead, the gaps in this research area, the need to improvise incorporating nanoaspects in metal complexes, and the need to test metal complex-based drugs in clinical trials have been discussed and deliberated. The pandemic shook the entire world and claimed quite a percentage of the global population. Metal complex-based drugs are already established for their antiviral property with respect to enveloped viruses and extrapolating them for COVID-19 can be an effective way to manipulate drug resistance and mutant issues that the current anti-COVID-19 drugs are facing.

Keywords: COVID-19; antiviral; cisplantin; mechanism; metal complexes; nanoparticles.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Validated medicinal properties of various metal/metal complexes.
Figure 2
Figure 2
The unique chemical characteristics of metal complexes add up to their antiviral property.
Figure 3
Figure 3
Three modes of contribution from metal complexes towards the anti-COVID-19 activity.
See this image and copyright information in PMC

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