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Review
. 2023 Mar 24;16(4):487.
doi: 10.3390/ph16040487.

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Elham Assadpour  1   2 , Atefe Rezaei  3 , Sabya Sachi Das  4   5 , Balaga Venkata Krishna Rao  4 , Sandeep Kumar Singh  4 , Mohammad Saeed Kharazmi  6 , Niraj Kumar Jha  7   8 , Saurabh Kumar Jha  7   9   10 , Miguel A Prieto  11 , Seid Mahdi Jafari  11   12   13
Affiliations
Review

Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Elham Assadpour et al. Pharmaceuticals (Basel). .

Abstract

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

Keywords: Cannabis sativa; bioavailability; cannabidiol; molecular mechanism; nanomedicine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Major classification of cannabinoids (dibenzopyranes, benzopyranes, and acyclic prenyl-olivetols) based on the tetrahydro-diphenyl skeleton.
Figure 2
Figure 2
Major interactions between CBD and several membrane receptors. Blue arrows indicate agonist activity; red arrows indicate antagonist activity.
Figure 3
Figure 3
Various nanocarriers improve the targetability and therapeutic efficacy of CBD.
Figure 4
Figure 4
Schematic representation of release mechanisms from nanocarriers permeating via various biological barriers.
See this image and copyright information in PMC

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