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. 2023 Mar 27;11(4):741.
doi: 10.3390/vaccines11040741.

Effectiveness of the Air-Filled Technique to Reduce the Dead Space in Syringes and Needles during ChAdox1-n CoV Vaccine Administration

Naphatthorn Prueksaanantakal  1 , Anan Manomaipiboon  2 , Patchara Phankavong  2 , Warissara Jirawathin  2 , Nontawat Benjakul  2 , Jakravoot Maneerit  2 , Uraporn Phumisantiphong  2 , Thananda Trakarnvanich  2
Affiliations

Effectiveness of the Air-Filled Technique to Reduce the Dead Space in Syringes and Needles during ChAdox1-n CoV Vaccine Administration

Naphatthorn Prueksaanantakal et al. Vaccines (Basel). .

Abstract

In the current study, we calculated the vaccine volume and amount of dead space in a syringe and needle during ChAdox1-n CoV vaccine administration using the air-filled technique. The aim is to reduce the dead space in syringes and needles in order to administer up to 12 doses per vial. The hypothetical situation uses a vial with a similar size as the ChAdox1-n CoV vial. We used distilled water (6.5 mL) to fill the same volume as five vials of ChAdox1-n CoV. When 0.48 mL of distilled water is drawn according to the number on the side of the barrel, an additional 0.10 mL of air can be used in the dead space of the distilled water in the syringe and needle for 60 doses, which can be divided into an average of 0.5 mL per dose. ChAdox1-n CoV was administered using a 1-mL syringe and 25G needle into 12 doses using this air-filled technique. The volume of the recipient vaccine will increase by 20% and save on the budget for low dead space syringes (LDS).

Keywords: COVID-19; ChAdox1-n CoV vaccine; air-filled technique; low dead space syringe.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
General space syringe and needle.
Figure 2
Figure 2
Low dead space syringe and needle.
Figure 3
Figure 3
Comparison of vaccine weights by using the air-filled technique. Before: Weight of the empty syringe and needle. Preparation: Filled syringe with the vaccine. After preparation: Weights of the syringe and needle after injection.
See this image and copyright information in PMC

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