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Review
. 2023 Apr 2;11(4):785.
doi: 10.3390/vaccines11040785.

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

Cecilia Righi  1 , Giulia Franzoni  2 , Francesco Feliziani  1 , Clinton Jones  3 , Stefano Petrini  1
Affiliations
Review

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

Cecilia Righi et al. Vaccines (Basel). .

Abstract

Bovine Alphaherpesvirus 1 (BoHV-1) is one of the major respiratory pathogens in cattle worldwide. Infection often leads to a compromised host immune response that contributes to the development of the polymicrobial disease known as "bovine respiratory disease". After an initial transient phase of immunosuppression, cattle recover from the disease. This is due to the development of both innate and adaptive immune responses. With respect to adaptive immunity, both humoral and cell-mediated immunity are required to control infection. Thus, several BoHV-1 vaccines are designed to trigger both branches of the adaptive immune system. In this review, we summarize the current knowledge on cell-mediated immune responses directed against BoHV-1 infection and vaccination.

Keywords: BoHV-1; cell-mediated immunity; humoral immunity; infection; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

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