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Review
. 2023 Apr 2;11(4):785.
doi: 10.3390/vaccines11040785.

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

Cecilia Righi  1 , Giulia Franzoni  2 , Francesco Feliziani  1 , Clinton Jones  3 , Stefano Petrini  1
Affiliations
Review

The Cell-Mediated Immune Response against Bovine alphaherpesvirus 1 (BoHV-1) Infection and Vaccination

Cecilia Righi et al. Vaccines (Basel). .

Abstract

Bovine Alphaherpesvirus 1 (BoHV-1) is one of the major respiratory pathogens in cattle worldwide. Infection often leads to a compromised host immune response that contributes to the development of the polymicrobial disease known as "bovine respiratory disease". After an initial transient phase of immunosuppression, cattle recover from the disease. This is due to the development of both innate and adaptive immune responses. With respect to adaptive immunity, both humoral and cell-mediated immunity are required to control infection. Thus, several BoHV-1 vaccines are designed to trigger both branches of the adaptive immune system. In this review, we summarize the current knowledge on cell-mediated immune responses directed against BoHV-1 infection and vaccination.

Keywords: BoHV-1; cell-mediated immunity; humoral immunity; infection; vaccines.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. International Committee on Taxonomy of Viruses: ICTV. [(accessed on 20 January 2023)]. Available online: https://ictv.global/taxonomy/taxondetails?taxnode_id=202101442.
    1. Iscaro C., Cambiotti V., Petrini S., Feliziani F. Control programs for infectious bovine rhinotracheitis (IBR) in European countries: An overview. Anim. Health Res. Rev. 2021;22:136–146. doi: 10.1017/S1466252321000116. - DOI - PubMed
    1. Maresca C., Scoccia E., Dettori E., Felici A., Guarcini R., Petrini S., Quaglia A., Filippini G. National surveillance plan for infectious bovine rhinotracheitis (IBR) in autochthonous Italian cattle breeds: Results of first year of activity. Vet. Microbiol. 2018;219:150–153. doi: 10.1016/j.vetmic.2018.04.013. - DOI - PubMed
    1. Tamba M., Pallante I., Petrini S., Feliziani F., Iscaro C., Arrigoni N., Di Sabatino D., Barberio A., Cibin V., Santi A., et al. Corrigendum: Overview of Control Programs for Twenty-Four Infectious Cattle Diseases in Italy. Front. Vet. Sci. 2021;7:818480. doi: 10.3389/fvets.2021.818480. - DOI - PMC - PubMed
    1. Regulation (EU) 2016/429 of the European Parliament and of the Council of 9 March 2016, on transmissible animal diseases and amending and repealing certain acts in the area of animal health (Animal Health Law) [(accessed on 5 January 2023)];Off. J. Eur. Union. 2016 84:1–208. Available online: https://eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=CELEX:32016R0429....

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