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. 2023 Apr 11:10:1156006.
doi: 10.3389/fnut.2023.1156006. eCollection 2023.

Clinical significance of the controlling nutritional status (CONUT) score in gastric cancer patients: A meta-analysis of 9,764 participants

Hui Liu #  1 , Xiao-Chuan Yang #  1 , Ding-Cheng Liu  1 , Chao Tong  1 , Wen Wen  2 , Ri-Hui Chen  1
Affiliations

Clinical significance of the controlling nutritional status (CONUT) score in gastric cancer patients: A meta-analysis of 9,764 participants

Hui Liu et al. Front Nutr. .

Abstract

Background: The clinical value of the controlling nutritional status (CONUT) score has been widely reported in multiple malignancies. The aim of this study is to investigate the association between the CONUT score and clinical outcomes in patients with gastric cancer.

Methods: A comprehensive literature search of electronic databases including PubMed, Embase, and Web of Science was performed up to December 2022. The primary endpoints were survival outcomes and postoperative complications. Subgroup analysis and sensitivity analysis were performed during the pooled analysis.

Results: Nineteen studies including 9,764 patients were included. The pooled results indicated that patients in the high CONUT group had a worse overall survival (HR = 1.70 95%CI: 1.54-1.87; P < 0.0001; I 2 = 33%) and recurrence-free survival (HR = 1.57; 95%CI: 1.36-1.82; P < 0.0001; I 2 = 30%), and a higher risk of complications (OR = 1.96; 95%CI: 1.50-2.57; P < 0.0001; I 2 = 69%). In addition, a high CONUT score was significantly associated with larger tumor size, higher percentage of microvascular invasion, later TNM stage and fewer patients receiving adjuvant chemotherapy, but not with tumor differentiation.

Conclusion: Based on existing evidence, the CONUT score could act as a valuable biomarker to predict clinical outcomes in patients with gastric cancer. Clinicians could use this useful indicator to stratify patients and formulate individual treatment plans.

Keywords: controlling nutritional status score; gastric cancer; meta-analysis; postoperative complications; survival outcomes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The PRISMA flowchart of study selection.
FIGURE 2
FIGURE 2
Quality assessment of included studies.
FIGURE 3
FIGURE 3
Forest plot assessing the relationship between the CONUT and OS.
FIGURE 4
FIGURE 4
Forest plot accessing the relationship between the CONUT and RFS.
FIGURE 5
FIGURE 5
Forest plot assessing the relationship between the CONUT and postoperative complications.
See this image and copyright information in PMC

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