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Case Reports
. 2023 Apr 14;18(6):2245-2248.
doi: 10.1016/j.radcr.2023.03.023. eCollection 2023 Jun.

An atypical presentation of granulomatosis with polyangiitis: A case report

Umar Maqbool  1 , Abdullah Maqbool  2 , Ayesha Maqbool  3 , Ahsan Qadeer  4 , Muhammad Fayzan Mehmood  4 , Muaz Loon  4
Affiliations
Case Reports

An atypical presentation of granulomatosis with polyangiitis: A case report

Umar Maqbool et al. Radiol Case Rep. .

Abstract

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crusting and nasal obstruction. He had been operated on twice for sinonasal polyposis. Relevant investigations revealed that he was actually suffering from GPA. The patient was started on remission induction therapy. A combination of methotrexate and prednisolone was started with a 2-weekly follow-up. The patient had experienced his symptoms for 2 years before presentation. This case highlights the importance of correlating ENT and pulmonary symptoms to reach the correct diagnosis.

Keywords: Antineutrophil cytoplasmic antibodies; Granulomatosis with polyangiitis; Sinonasal polyposis; Sinusitis; Systemic vasculitis.

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Figures

Fig 1:
Fig. 1
Lateral view shows saddle-nose deformity.
Fig 2:
Fig. 2
Nasal speculum examination shows septal perforation.
Fig 3:
Fig. 3
HRCT chest axial images show multifocal consolidation areas bilaterally. Areas of ground glass haze are seen in both lung fields.
See this image and copyright information in PMC

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