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. 2023 Apr 21:16:1471-1478.
doi: 10.2147/IJGM.S409183. eCollection 2023.

ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Songsheng Zhang  1   2 , Weiwen Luo  1   2 , Tingjun Pan  1   2 , Jieyao Xie  1   2 , Zhou Xu  1   2 , Yuquan Fang  1   2
Affiliations

ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

Songsheng Zhang et al. Int J Gen Med. .

Abstract

Background: Hypertension is the main risk factor for hemorrhagic stroke. Aldehyde dehydrogenase 2 (ALDH2) may inhibit the occurrence of hypertension by anti-oxidative stress and vascular dilation. The purpose was to investigate the relationship of ALDH2 polymorphisms with hemorrhagic stroke in Hakka Chinese.

Methods: A total of 329 patients with hemorrhagic stroke and 515 controls were enrolled, and medical records (smoking and drinking history, hypertension, and diabetes) were collected. The genotypes of ALDH2 rs671 of the two groups were detected and analyzed.

Results: The proportion of the ALDH2 rs671 G/G, G/A, and A/A genotype in patients with hemorrhagic stroke was 55.9%, 37.4%, and 6.7%, respectively, while those were 65.0%, 30.7%, and 4.3% in controls, respectively. There was statistically significant difference in ALDH2 rs671 genotypes distribution (P=0.021) and alleles distribution (P=0.005) between patients and controls. Among hemorrhagic stroke patients, no statistically significant differences were observed between patients with ALDH2 different genotypes. Logistic regression analysis showed that there was significantly high risk of hemorrhagic stroke in men (male vs female: adjusted OR 1.711, 95% CI 1.154-2.538, P=0.008), the presence of hypertension (with vs without hypertension: adjusted OR 16.095, 95% CI 10.958-23.641, P<0.001), and the presence of ALDH2 rs671 G/A genotype (G/A vs G/G: adjusted OR 1.679, 95% CI 1.151-2.450, P=0.007) or A/A genotype (A/A vs G/G: adjusted OR 2.516, 95% CI 1.132-5.591, P=0.024).

Conclusion: ALDH2 rs671 polymorphism likely a risk factor for hemorrhagic stroke.

Keywords: ALDH2; Hakka; hemorrhagic stroke; polymorphism.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. Hathidara MY, Saini V, Malik AM. Stroke in the young: a global update. Curr Neurol Neurosci Rep. 2019;19(11):91. doi:10.1007/s11910-019-1004-1 - DOI - PubMed
    1. Welten S, Onland-Moret NC, Boer JMA, Verschuren WMM, van der Schouw YT. Age at menopause and risk of ischemic and hemorrhagic stroke. Stroke. 2021;52(8):2583–2591. doi:10.1161/STROKEAHA.120.030558 - DOI - PMC - PubMed
    1. Hostettler IC, Seiffge DJ, Werring DJ. Intracerebral hemorrhage: an update on diagnosis and treatment. Expert Rev Neurother. 2019;19(7):679–694. doi:10.1080/14737175.2019.1623671 - DOI - PubMed
    1. GBD. 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol. 2021;20(10):795–820. doi:10.1016/S1474-4422(21)00252-0 - DOI - PMC - PubMed
    1. Ma Q, Li R, Wang L, et al. Temporal trend and attributable risk factors of stroke burden in China, 1990–2019: an analysis for the global burden of disease study 2019. Lancet Public Health. 2021;6(12):e897–e906. doi:10.1016/S2468-2667(21)00228-0 - DOI - PMC - PubMed