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Review
. 2023 Apr 28;31(5):306.
doi: 10.1007/s00520-023-07749-9.

Quality assessment of PBM protocols for oral complications in head and neck cancer patients: part 2

Margherita Gobbo  1 , Praveen R Arany  2 , Elisabetta Merigo  3 , René-Jean Bensadoun  4 , Alan Roger Santos-Silva  5 , Luiz Alcino Gueiros  6 , Giulia Ottaviani  7
Affiliations
Review

Quality assessment of PBM protocols for oral complications in head and neck cancer patients: part 2

Margherita Gobbo et al. Support Care Cancer. .

Abstract

Purpose: To investigate the role of photobiomodulation (PBM) in patients undergoing head and neck cancer (HNC) treatment. We focused on the consequences of the main complications, such as quality of life (QoL), analgesia, functional impairment, and nutritional status, as well as on the impact on survival/ recurrences, radiotherapy (RT) interruption, adherence, cost-effectiveness, safety, feasibility, and tolerability.

Methods: An electronic search in PubMed and Scopus databases was performed. Full texts were carefully assessed, and data were assimilated into a tabular form for discussion and consensus among the expert panel.

Results: A total of 22 papers were included. Overall, a beneficial effect of PBM was evidenced in the amelioration of QoL, nutritional status, the reduction of pain, and functional impairment. Preventive PBM may reduce the incidence and duration of RT interruptions, potentially contributing to improved cancer treatment outcomes. PBM treatments are safe and recommended for routine use, with the caveat of avoiding direct tumor exposures where feasible. However, it does not appear to impact cancer survivorship/recurrences directly. Despite additional clinical efforts involving routine PBM use, the individual and public health benefits will positively impact oncology care.

Conclusions: Quality of life, pain and functional impairment, nutritional status, and survival may be effectively improved with PBM. Given its established efficacy also in reducing RT interruptions and its safety, feasibility, and tolerability, PBM should be included in the field of supportive cancer care in HNC patients. Improved understanding of PBM mechanisms and precise dose parameters is enabling the generation of more robust, safe, and reproducible protocols; thus, it is imperative to support further clinical implementation as well as both applied and basic science research in this novel field.

Keywords: Head and neck neoplasms; Laser therapy; Nutritional status; Pain; Photobiomodulation; Quality of life.

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References

    1. Gobbo M, Merigo E, Arany PR et al (2022) Quality assessment of PBM protocols for oral complications in head and neck cancer patients: part 1. Front Oral Health 3:945718. https://doi.org/10.3389/froh.2022.945718 - DOI - PubMed - PMC
    1. Bellm LA, Epstein JB, Rose-Ped A et al (2000) Patient reports of complications of bone marrow transplantation. Support Care Cancer Off J Multinatl Assoc Support Care Cancer 8:33–39. https://doi.org/10.1007/s005209900095 - DOI
    1. Adelstein DJ, Li Y, Adams GL et al (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol Off J Am Soc Clin Oncol 21:92–98. https://doi.org/10.1200/JCO.2003.01.008 - DOI
    1. Epstein JB, Beaumont JL, Gwede CK et al (2007) Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire. Cancer 109:1914–1922. https://doi.org/10.1002/cncr.22620 - DOI - PubMed
    1. Kelly C, Paleri V, Downs C, Shah R (2007) Deterioration in quality of life and depressive symptoms during radiation therapy for head and neck cancer. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 136:108–111. https://doi.org/10.1016/j.otohns.2006.06.1278 - DOI

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