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Editorial
. 2023 Jul 5;29(13):2342-2344.
doi: 10.1158/1078-0432.CCR-23-0736.

Time to Introduce Nerve Density in Cancer Histopathologic Assessment

Hubert Hondermarck  1   2 , Chen Chen Jiang  1   2
Affiliations
Editorial

Time to Introduce Nerve Density in Cancer Histopathologic Assessment

Hubert Hondermarck et al. Clin Cancer Res. .

Abstract

The density of nerves in the tumor microenvironment is increasingly reported to be associated with worse clinical outcome in various cancers. Therefore, it is time to consider the assessment of nerve density in clinical cancer pathology, and interestingly, the development of artificial intelligence may facilitate this clinical translation. See related article by Perez-Pacheco et al., p. 2501.

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Comment in

  • Increased Nerve Density Adversely Affects Outcome in Oral Cancer.
    Perez-Pacheco C, Schmitd LB, Furgal A, Bellile EL, Liu M, Fattah A, Gonzalez-Maldonado L, Unsworth SP, Wong SY, Rozek LS, Rao A, Wolf GT, Taylor JMG, Casper K, Mierzwa M, D'Silva NJ. Perez-Pacheco C, et al. Clin Cancer Res. 2023 Jul 5;29(13):2501-2512. doi: 10.1158/1078-0432.CCR-22-3496. Clin Cancer Res. 2023. PMID: 37039710 Free PMC article.

Comment on

  • Increased Nerve Density Adversely Affects Outcome in Oral Cancer.
    Perez-Pacheco C, Schmitd LB, Furgal A, Bellile EL, Liu M, Fattah A, Gonzalez-Maldonado L, Unsworth SP, Wong SY, Rozek LS, Rao A, Wolf GT, Taylor JMG, Casper K, Mierzwa M, D'Silva NJ. Perez-Pacheco C, et al. Clin Cancer Res. 2023 Jul 5;29(13):2501-2512. doi: 10.1158/1078-0432.CCR-22-3496. Clin Cancer Res. 2023. PMID: 37039710 Free PMC article.

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