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. 2023 Apr 28;18(4):e0285348.
doi: 10.1371/journal.pone.0285348. eCollection 2023.

Expression of Concern: Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis

PLOS ONE Editors

Expression of Concern: Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis

PLOS ONE Editors. PLoS One. .
No abstract available

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Figures

Fig 2
Fig 2. Results of the meta-analysis on pooled HR values.
Each square denotes the HR for that trial comparison with the horizontal lines showing the 95% CIs. The size of the square is directly proportional to the amount of information contributed by the trial. The hollow blue diamond gives the pooled HR from the random effect model; the centre of this diamond denotes the HR and the extremities the 95% CI.
Fig 3
Fig 3. Result of sensitivity analysis.
The middle vertical line indicates the combined HR, and the two vertical lines represent the corresponding 95% CI values. The middle small circle and two ends of the dotted lines indicate the pooled HR and 95% CI values, respectively, when the study on the left was omitted after each round of analysis.
Fig 4
Fig 4. Begg’s funnel plot to evaluate OS.
Funnel plot showing symmetry indicative of no evidence of publication bias for OS.
See this image and copyright information in PMC

Expression of concern for

References

    1. Li B, Tang H, Zhang A, Dong J (2016) Prognostic Role of Mucin Antigen MUC4 for Cholangiocarcinoma: A Meta-Analysis. PLoS ONE 11(6): e0157878. 10.1371/journal.pone.0157878 - DOI - PMC - PubMed
    1. Tamada S, Shibahara H, Higashi M, Goto M, Batra SK, Imai K, et al.. MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma. Clin Cancer Res. 2006; 12: 4257–4264. doi: 10.1158/1078-0432.CCR-05-2814 - DOI - PubMed
    1. Yeh CN, Pang ST, Wu RC, Chen TW, Jan YY, Chen MF. Prognostic value of MUC4 for mass-forming intrahepatic cholangiocarcinoma after hepatectomy. Oncol Rep. 2009; 21: 49–56 - PubMed
    1. Yanyu H. Expression and signification of MUC3 and MUC4 in hepatolithiasis associated intrahepatic cholangiocarcinoma. scholarly journal. M.Sc. Thesis, The University of south China, 2012

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