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. 2023 Jun:173:106-113.
doi: 10.1016/j.ygyno.2023.04.006. Epub 2023 Apr 26.

Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature

Luiza Perez  1 , Emily Webster  1 , Leslie Bull  1 , Jesse T Brewer  1 , Muhammad Danyal Ahsan  1 , Jenny Lin  1 , Sarah R Levi  1 , Evelyn Cantillo  1 , Eloise Chapman-Davis  1 , Kevin Holcomb  1 , Shoshana M Rosenberg  1 , Melissa K Frey  2
Affiliations

Patient perspectives on risk-reducing salpingectomy with delayed oophorectomy for ovarian cancer risk-reduction: A systematic review of the literature

Luiza Perez et al. Gynecol Oncol. 2023 Jun.

Abstract

Objective: Increasing evidence suggests the fallopian tube as the site of origin of BRCA1/2-associated high-grade ovarian cancers. Several ongoing trials are evaluating salpingectomy with delayed oophorectomy (RRSDO) for ovarian cancer risk reduction and patients are beginning to ask their clinicians about this surgical option. This study sought to systematically review the available literature examining patient preferences regarding RRSDO and risk-reducing salpingo-oophorectomy (RRSO) to provide clinicians with an understanding of patient values, concerns, and priorities surrounding ovarian cancer risk-reducing surgery.

Methods: We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO No.: CRD42023400690). We searched key electronic databases to identify studies evaluating acceptance and surgical decision-making regarding RRSO and RRSDO among patients with an increased risk of ovarian cancer.

Results: The search yielded 239 results, among which six publications met the systematic review inclusion criteria. Acceptance of RRSDO was evaluated in all studies and ranged from 34% to 71%. Factors positively impacting patients' acceptance of RRSDO included: avoidance of surgical menopause, preservation of fertility, concerns about sexual dysfunction, family history of breast cancer, and avoidance of hormone replacement therapy. Factors limiting this acceptance reported by patients included concerns regarding oncologic safety, surgical timing, and surgical complications.

Conclusion: To date, few studies have explored patient perspectives surrounding RRSDO. Collectively, the limited data available indicate a high level of acceptance among BRCA1/2 carriers, and provides insight regarding both facilitating and limiting factors associated with patient preferences to better equip clinicians in the counseling and support of their patients.

Keywords: BRCA1; BRCA2; Hereditary cancer syndromes; Ovarian cancer; Patient preferences; Risk-reducing salpingectomy with delayed oophorectomy (RRSDO); Risk-reducing salpingo-oophorectomy.

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Conflict of interest statement

Conflict of Interest Disclosures:

Kevin Holcomb: Johnson and Johnson: Consultant. Fujirebio Diagnostics: Research support.

Shoshana Rosenberg: Pfizer/Conquer Cancer: Research support.

Figures

Figure 1:
Figure 1:
PRISMA flowchart of systematic review process and study selection
See this image and copyright information in PMC

References

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