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. 2023 Apr 27;186(9):1821-1823.
doi: 10.1016/j.cell.2023.03.022.

Translocating Lactobacillus torments tumors via tryptophan catabolism

Márcia S Pereira  1 , Martin A Kriegel  2
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Translocating Lactobacillus torments tumors via tryptophan catabolism

Márcia S Pereira et al. Cell. .
Free article

Abstract

Variability in the efficacy of immune checkpoint inhibitors in cancer patients is associated with the human gut microbiota. However, detailed mechanisms are unclear. In this issue of Cell, Bender et al. uncovered that a probiotic Lactobacillus strain translocates into murine tumors to enhance immunotherapy via the tryptophan metabolite indole-3-aldehyde (I3A).

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Conflict of interest statement

Declaration of interests M.A.K. received salary, consulting fees, honoraria, or research funds from Eligo Biosciences, Enterome, Roche, Novartis, Bristol–Meyers Squibb, AbbVie, GlaxoSmithKline, MSD Sharpe & Dohme, and Cell Applications, and holds a patent on the use of microbiota manipulations to treat immune-mediated diseases. M.S.P. declares no competing interests.

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