Counteracting Alzheimer's disease via somatic TERT activation

Yuan Fu¹, Guojun Bu^{2

3}, Takahisa Kanekiyo^{2

3}, Jing Zhao^{4

5}

Affiliations

¹ Department of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China.
² Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
³ Neuroregeneration Laboratory, Center for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA.
⁴ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Zhao.Jing@mayo.edu.
⁵ Neuroregeneration Laboratory, Center for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA. Zhao.Jing@mayo.edu.

Comment

Yuan Fu et al. Nat Aging. 2021 Dec.

. 2021 Dec;1(12):1081-1082.

doi: 10.1038/s43587-021-00145-0.

Yuan Fu¹, Guojun Bu^{2

3}, Takahisa Kanekiyo^{2

3}, Jing Zhao^{4

5}

¹ Department of Neurology, The Fourth Hospital of Harbin Medical University, Harbin, China.
² Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
³ Neuroregeneration Laboratory, Center for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA.
⁴ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Zhao.Jing@mayo.edu.
⁵ Neuroregeneration Laboratory, Center for Regenerative Medicine, Mayo Clinic, Jacksonville, FL, USA. Zhao.Jing@mayo.edu.

No abstract available

Comment on

Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models.
Shim HS, Horner JW, Wu CJ, Li J, Lan ZD, Jiang S, Xu X, Hsu WH, Zal T, Flores II, Deng P, Lin YT, Tsai LH, Wang YA, DePinho RA. Shim HS, et al. Nat Aging. 2021 Dec;1(12):1162-1174. doi: 10.1038/s43587-021-00146-z. Epub 2021 Dec 20. Nat Aging. 2021. PMID: 35036927 Free PMC article.

1. Aubert, G. & Lansdorp, P. M. Physiol. Rev. 88, 557–579 (2008). - DOI
1. Autexier, C. & Lue, N. F. Annu. Rev. Biochem. 75, 493–517 (2006). - DOI
1. Shim, H. S. et al. Nat. Aging https://doi.org/10.1038/s43587-021-00146-z (2021). - DOI
1. Spilsbury, A., Miwa, S., Attems, J. & Saretzki, G. J. Neurosci. 35, 1659–1674 (2015). - DOI
1. Zhu, H., Fu, W. & Mattson, M. P. J. Neurochem. 75, 117–124 (2000). - DOI