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. 2023 Jan;7(1):3-4.
doi: 10.1038/s41570-022-00451-0.

Rules were made to be broken

Affiliations

Rules were made to be broken

Ingo V Hartung et al. Nat Rev Chem. 2023 Jan.
No abstract available

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References

    1. Lipinski, C. A., Lombardo, F., Dominy, B. W. & Feeney, P. J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3–25 (1997). - DOI
    1. Shultz, M. D. Two Decades under the influence of the rule of five and the changing properties of approved oral drugs. J. Med. Chem. 62, 1701–1714 (2019). - DOI
    1. Dowden, H. & Munro, J. Trends in clinical success rates and therapeutic focus. Nat. Rev. Drug Discov. 18, 495–496 (2019). - DOI
    1. Jhoti, H., Williams, G., Rees, D. C. & Murray, C. W. The ‘rule of three’ for fragment-based drug discovery: where are we now? Nat. Rev. Drug Discov. 12, 644 (2013). - DOI
    1. Young, R. J. & Leeson, P. D. Mapping the efficiency and physicochemical trajectories of successful optimizations. J. Med. Chem. 61, 6421–6467 (2018). - DOI

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