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. 2023 Jun;68(6):2493-2500.
doi: 10.1007/s10620-023-07953-x. Epub 2023 Apr 29.

Comparable Short-Term Weight Loss and Safety of Endoscopic Sleeve Gastroplasty in Diabetic and Non-diabetic Patients

Hassam Ali  1 , Fouad Jaber  2 , Pratik Patel  3 , Dushyant Singh Dahiya  4 , Shiza Sarfraz  5 , Saeed Graham  6 , Muhammad Fahd Farooq  1 , Babu P Mohan  7 , Douglas G Adler  8
Affiliations

Comparable Short-Term Weight Loss and Safety of Endoscopic Sleeve Gastroplasty in Diabetic and Non-diabetic Patients

Hassam Ali et al. Dig Dis Sci. 2023 Jun.

Abstract

Background: Endoscopic sleeve gastroplasty (ESG) is a highly effective endo bariatric procedure. Data on outcomes of ESG in patients with diabetes mellitus (DM) compared to non-diabetics are limited.

Aims: We aim to assess differences in clinical outcomes of ESG in DM patients in North America.

Methods: We used the Metabolic and Bariatric Surgery Accreditation Quality Improvement Program database from 2016 to 2021 to identify all DM patients who underwent ESG as the primary procedure for weight loss. A 1:1 propensity score matched cohort of non-DM patients served as controls. Patient characteristics, clinical outcomes, and complications were compared and analyzed. Adult patients with Class I obesity and above were included.

Results: After matching, 310 DM and non-DM patients that underwent ESG were compared. The median % BMI decrease (3.3% vs. 3.1%, P = 0.62) and median total body weight loss (%TBWL) (4.3% vs. 4%, P = 0.75) in 30 days were similar in the DM compared to non-DM cohorts. A similar proportion of patients with major adverse events (AEs) were present after ESG in the DM (1.6% vs. 1.3%, P = 0.74) compared to the non-DM cohort. The DM cohort had more patients with 30-day readmissions (3.2% vs. 1.9%, P = 0.08) than the non-DM cohort. %TBWL was similar in patients with HbA1c < 9% compared to ≥ 9%, (4.3% each, P = 0.33) with comparable AEs.

Conclusion: ESG is a safe procedure in DM patients, without an increase in AEs, and it shows similar short-term weight loss compared to non-DM patients.

Keywords: Bariatric surgery; Diabetes mellitus; Endoscopic sleeve gastroplasty; Obesity; Treatment outcome.

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