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Review
. 2023 Jul;40(4):223-237.
doi: 10.1053/j.semdp.2023.04.012. Epub 2023 Apr 25.

Application of immunohistochemical studies in diagnosing emerging superficial mesenchymal neoplasms

Kasey J McCollum  1 , Rami N Al-Rohil  2
Affiliations
Review

Application of immunohistochemical studies in diagnosing emerging superficial mesenchymal neoplasms

Kasey J McCollum et al. Semin Diagn Pathol. 2023 Jul.

Abstract

Molecular diagnostics, with the subsequent development of novel immunohistochemical markers, continues to advance and expand the field of soft tissue pathology. As such, the ever-evolving molecular diagnostic landscape will continue to shape and refine our understanding and classification of neoplasms. This article reviews the current literature on various tumors of mesenchymal origin, including fibroblastic/fibrohistiocytic, adipocytic, vascular, and tumors of uncertain origin. We aim to give the reader a detailed understanding and pragmatic approach to various new and established immunohistochemical stains in diagnosing these neoplasms and also discuss various pitfalls with significant repercussions.

Keywords: Immunohistochemistry; Sarcoma; Superficial mesenchymal neoplasms.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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