Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr 29;13(1):7040.
doi: 10.1038/s41598-023-34278-6.

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals

Halil İbrahim Ceylan  1 , Mehmet Ertuğrul Öztürk  1 , Deniz Öztürk  2 , Ana Filipa Silva  3   4   5 , Mevlüt Albayrak  2 , Özcan Saygın  6 , Özgür Eken  7 , Filipe Manuel Clemente  3   8 , Hadi Nobari  9   10
Affiliations

Acute effect of moderate and high-intensity interval exercises on asprosin and BDNF levels in inactive normal weight and obese individuals

Halil İbrahim Ceylan et al. Sci Rep. .

Abstract

This study aimed to examine the acute effects of moderate-intensity aerobic and high-intensity interval exercise protocols on Asprosin and Brain-Derived Neurotrophic Factor (BDNF) levels in inactive normal weight and obese individuals. A total of 20 male individuals aged 18-65 years, ten normal weight (NW) (Body Mass Index (BMI): 18.5-24.99 kg/m2) and 10 obese (Ob) (BMI: 24.99-35.00 kg/m2) participated in this study, voluntarily. Moderate aerobic exercise (AE) (main circuit 30 min, between 40 and 59% of Heart Rate Reserve: HRR) and High-Intensity Interval exercise (HIIE) running protocols (main circuit 20 min, between 75 and 90% of the HRR for 1 min*10 times, and 1-min active rest at 30% of the HRR) was applied to the volunteer participants in the morning hours (08.00-10.00 a.m.), following the night fasting (at least 8-10 h) for at least 3 days between each other. Blood samples were collected from the participants before and immediately after each exercise protocol, and serum asprosin and BDNF hormone levels were determined by Enzyme-Linked Immunosorbent Assay" method. Basal serum asprosin was found to be significantly higher in the Ob group compared to the NW group (p < .001), while the basal serum BDNF hormone was found to be lower (p < 0.05). It was observed that the serum asprosin level of both groups decreased significantly after both AE and HIIE protocols (p < 0.05). In addition, there was a significantly higher decrease in serum asprosin level in the Ob group compared to the NW group after HIIE protocol. For the Ob group, serum BDNF level increased considerably after HIIE protocol compared to AE protocol (p < 0.05). Serum asprosin was found to be higher in the Ob group, while the serum BDNF was found to be lower. In addition, the acute exercises of different intensity significantly affected hormones that regulate appetite metabolism. In particular, it was observed that the HIIE protocol had a greater effect on the regulation of appetite (hunger-satiety) in the Ob group. This result can be taken into account when planning training programs for these individuals.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Experimental design of the study.
Figure 2
Figure 2
Comparison of asprosin and BDNF (basal) levels of NW and Ob groups before AE and HIIE. *p < 0.05, ***p < .001, NW: Normal weight; Ob: Obese, AE: Aerobic Exercise; HIIE: High Intensity Interval Exercise.
Figure 3
Figure 3
Receiver Operating Characteristic (ROC) Curve Analysis of serum asprosin (A) and BDNF (B).
Figure 4
Figure 4
Serum asprosin levels (bar charts and scatter plots) of NW and Ob groups before and after AE and HIIE. NW: Normal weight; Ob: Obese, AE: Aerobic Exercise; HIIE: High Intensity Interval Exercise.
Figure 5
Figure 5
The changes (bar charts and scatter plots) in serum BDNF levels of NW and Ob groups before and after AE and HIIE. NW: Normal weight; Ob: Obese, AE: Aerobic Exercise; HIIE: High Intensity Interval Exercise.
See this image and copyright information in PMC

References

    1. Heine M, Lupton-Smith A, Pakosh M, Grace SL, Derman W, Hanekom SD. Exercise-based rehabilitation for major non-communicable diseases in low-resource settings: A scoping review. BMJ Glob. Health. 2019;4(6):e001833. doi: 10.1136/bmjgh-2019-001833. - DOI - PMC - PubMed
    1. Béland M, Lavoie KL, Briand S, White UJ, Gemme C, Bacon SL. Aerobic exercise alleviates depressive symptoms in patients with a major non-communicable chronic disease: A systematic review and meta-analysis. Br. J. Sports Med. 2020;54(5):272–278. doi: 10.1136/bjsports-2018-099360. - DOI - PubMed
    1. García-Mateo P, Ramirez-Campillo R, García-De-Alcaraz A, Rodríguez-Pérez M. A meta-analysis of the effects of strength training on arterial stiffness. Hum. Mov. 2023 doi: 10.5114/hm.2023.117126. - DOI
    1. Aarts H, Paulussen T, Schaalma H. Physical exercise habit: On the conceptualization and formation of habitual health behaviours. Health Educ. Res. 1997;12(3):363–374. doi: 10.1093/her/12.3.363. - DOI - PubMed
    1. Rivera-Brown AM, Frontera WR. Principles of exercise physiology: Responses to acute exercise and long-term adaptations to training. PM&R. 2012;4(11):797–804. doi: 10.1016/j.pmrj.2012.10.007. - DOI - PubMed

Publication types