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. 2023 Jul:168:105519.
doi: 10.1016/j.fitote.2023.105519. Epub 2023 Apr 29.

16,17-dinor-abietane diterpenoids from Casearia kurzii

Rui Li  1 , Xiao-Rong Sun  1 , Xiao-Ting He  1 , Xue-Mei Zhou  1 , Xue-Wen Wu  1 , Rui-Han Zhang  1 , Xing-Jie Zhang  1 , Xiao-Li Li  2 , Wei-Lie Xiao  3
Affiliations

16,17-dinor-abietane diterpenoids from Casearia kurzii

Rui Li et al. Fitoterapia. 2023 Jul.

Abstract

Eleven undescribed 16,17-dinor-abietane diterpenoids, caseazins A-K (1-11), and ten known diterpenoids (12-21) were isolated from the twigs and leaves of Casearia kurzii (Flacourtiaceae). Caseazins A-K were the first abietane -type dinorditerpenoids to have been isolated from the plant of Casearia kurzii. Their chemical structures were elucidated using a combination of 1D and 2D NMR spectroscopy and mass spectrometry. The absolute configurations of 5 and 10 were established by electronic circular dichroism calculations. Moreover, compounds 2, 3, 13, 14, and 18 exhibited anti-inflammatory activity with IC50 values of 0.17, 0.36, 6.55, 1.30, and 4.53 μM, respectively. IL-1β and caspase-1 analyses suggested that compound 14 inhibited NLRP3 inflammasome activation and blocked macrophage pyroptosis.

Keywords: 16,17-dinor-abietane diterpenoids; Anti-inflammatory; Casearia kurzii; Flacourtiaceae.

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Conflict of interest statement

Declaration of Competing Interest The authors declare no competing financial interest.

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