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Review
. 2023 Jun;12(2):100944.
doi: 10.1016/j.imr.2023.100944. Epub 2023 Apr 3.

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Li-Qing Niu  1   2 , Lu Xiao  3   2 , Qiu-Han Cai  1   2 , Yu-Yi Wu  1   2 , Si-Yuan Hu  1   2 , Sheng-Xuan Guo  1   2 , Yu-Ling Tian  1   2 , Qiu-Rong Wang  4
Affiliations
Review

Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis

Li-Qing Niu et al. Integr Med Res. 2023 Jun.

Abstract

Background: Rotavirus enteritis (RVE) accounts for 37% of all death in children (<5 years) with diarrhea. Chinese herbal injections (CHIs) have drawn more attention from practitioners because of the valid effects for RVE. However, the most beneficial one has not yet been determined.

Methods: Eight databases were searched from their inception up to September 3rd, 2022. The primary outcome was clinical effective rate and the secondary outcomes were time for disappearance of diarrhea, time of defervescence, time for disappearance of vomiting, and adverse drug reactions or adverse drug events. OpenBUGS 3.2.3 and STATA 14.0 software were employed to carry out the NMA.

Results: 58 randomized controlled trials (RCTs) with 6436 child patients were included in this Bayesian NMA. Four CHIs were investigated including Yanhuning injection (YHN), Xiyanping injection (XYP), Reduning injection (RDN), and Zedoary Turmeric Oil injection (ZTO). The results showed that YHN [OR=6.16, 95% CI (4.39, 8.77)] had a superior effect in improving clinical effective rate compared to Ribavirin based on Western medicine (WM). According to SUCRA values, YHN (84.1%) ranked highest. As for the secondary outcomes, XYP was the better intervention in shortening the time for disappearance of diarrhea. Regarding time for defervescence, RDN had obvious advantages and also performed well in time for disappearance of vomiting.

Conclusion: CHIs combined with WM could be beneficial than Ribavirin in improving clinical effective rate, and YHN was the optimum treatment. From the comprehensive evaluations of both the clinical effective rate and other outcomes, YHN also indicated a favorable therapeutic effect in RVE.

Study registration: PROSPERO, CRD42022357149.

Keywords: Bayesian network meta-analysis; Chinese herbal injections; Combination therapy; Rotavirus enteritis.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig 1
Fig. 1
Flow diagram of study inclusion.
Fig 2
Fig. 2
Network graph of the different outcomes. (A) Clinical effective rate; (B) Time for disappearance of diarrhea; (C) Time for defervescence; (D) Time for disappearance of vomiting.
Fig 3
Fig. 3
Risk of bias graph. (A) Risk of bias graph; (B) Risk of bias summary.
Fig 4
Fig. 4
Plot of SUCRA for all different outcomes. (A) Clinical effective rate; (B) Time for disappearance of diarrhea; (C) Time for defervescence; (D) Time for disappearance of vomiting.
Fig 5
Fig. 5
Cluster analysis plot for 4 outcomes. (A) Time for disappearance of diarrhea; (B) Time for defervescence; (C) Time for disappearance of vomiting.
See this image and copyright information in PMC

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