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Editorial
. 2023 Apr 12:16:1185637.
doi: 10.3389/fnmol.2023.1185637. eCollection 2023.

Editorial: Multi-limbed membrane guanylate cyclase cellular signaling pathways

Rameshwar K Sharma  1 , Kailash N Pandey  2 , Teresa Duda  1 , Clint L Makino  3
Affiliations
Editorial

Editorial: Multi-limbed membrane guanylate cyclase cellular signaling pathways

Rameshwar K Sharma et al. Front Mol Neurosci. .
No abstract available

Keywords: GC-A; GCAP; RD3; ROS-GC; cyclic GMP; mutant mouse; receptor guanylate cyclase; retina.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Multi-limbed membrane guanylate cyclase signaling. Seven subfamily forms of membrane guanylate cyclases, encoded by distinct genes, perform a multitude of functions. These uniquely designed surface receptors are all single-pass transmembrane proteins that detect hormones and other extracellular chemicals at an extracellular domain (EXT), translate the signal across a transmembrane domain (TM) to a catalytic regulatory module (CRM) and a catalytic core domain (CCD) to regulate cGMP synthesis. Together, they control steroidogenesis, cardiovasculature, sensory neurons in vision, taste and smell, the intestine, skeletal growth, and CNS plasticity.
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