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Editorial
. 2023 Apr 10;12(2):239-243.
doi: 10.21037/hbsn-23-6. Epub 2023 Mar 27.

Clinical practice guidelines for acute-on-chronic liver failure: are we ready for reaching global consensus?

Cornelius Engelmann  1   2   3   4 , Thomas Berg  2
Affiliations
Editorial

Clinical practice guidelines for acute-on-chronic liver failure: are we ready for reaching global consensus?

Cornelius Engelmann et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Acute-on-chronic liver failure (ACLF); cirrhosis; granulocyte-colony stimulating factor (G-CSF).

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-23-6/coif). CE reports grants from EU-Horizon 2020, Else-Kroener Fresenius and Albireo, reports royalties from Hepyx Ltd., honoraria from Albireo, Novartis, Intercept/Advanz Pharma. TB reports grants from Abbvie, BMS, Gilead, MSD/Merck, Humedics, Intercept, Merz, Norgine, Novartis, Orphalan and Sequana Medical, consulting fees from Abbvie, Alexion, Bayer, Gilead, GSK, Eisai, Enyo Pharma, HepaRegeniX GmbH, Humedics, Intercept, Ipsen, Janssen, MSD/Merck, Novartis, Orphalan, Roche, Sequana Medical, SIRTEX, SOBI, and Shionogi, payment or honoraria from Abbvie, Alexion, Bayer, Gilead, Eisai, Falk Foundation, Intercept, Ipsen, Janssen, MedUpdate GmbH, MSD/Merck, Novartis, Orphalan, Sequana Medica, SIRTEX, and SOBI, support for attending meetings from Gilead, Abbvie, Intercept and Janssen. The authors have no other conflicts of interest to declare.

Figures

Figure 1
Figure 1
Achieving a global consensus on ACLF (prepared with BioRender®). ACLF, acute-on-chronic liver failure; NACSELD, North American Consortium for the Study of End-Stage Liver Disease; EASL-CLIF, European Association for the Study of the Liver-Chronic Liver Failure; APASL, Asian-Pacific Association for the Study of the Liver.
See this image and copyright information in PMC

Comment on

  • Acute-on-Chronic Liver Failure Clinical Guidelines.
    Bajaj JS, O'Leary JG, Lai JC, Wong F, Long MD, Wong RJ, Kamath PS. Bajaj JS, et al. Am J Gastroenterol. 2022 Feb 1;117(2):225-252. doi: 10.14309/ajg.0000000000001595. Am J Gastroenterol. 2022. PMID: 35006099 Review.

References

    1. Sarin SK, Choudhury A, Sharma MK, et al. Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update. Hepatol Int 2019;13:353-90. 10.1007/s12072-019-09946-3 - DOI - PMC - PubMed
    1. O'Leary JG, Reddy KR, Garcia-Tsao G, et al. NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis. Hepatology 2018;67:2367-74. 10.1002/hep.29773 - DOI - PubMed
    1. Moreau R, Jalan R, Gines P, et al. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology 2013;144:1426-37, 1437.e1-9. - PubMed
    1. Bajaj JS, O'Leary JG, Lai JC, et al. Acute-on-Chronic Liver Failure Clinical Guidelines. Am J Gastroenterol 2022;117:225-52. 10.14309/ajg.0000000000001595 - DOI - PubMed
    1. Engelmann C, Clària J, Szabo G, et al. Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction. J Hepatol 2021;75 Suppl 1:S49-66. 10.1016/j.jhep.2021.01.002 - DOI - PMC - PubMed