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Comment
. 2023 Apr 10;12(2):291-293.
doi: 10.21037/hbsn-22-632. Epub 2023 Mar 27.

The association between sarcopenia and cirrhosis: a Mendelian randomization analysis

Shu Ran #  1   2 , Jia Yao #  1 , Baolin Liu  1   2
Affiliations
Comment

The association between sarcopenia and cirrhosis: a Mendelian randomization analysis

Shu Ran et al. Hepatobiliary Surg Nutr. .
No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-22-632/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
MR estimates using the IVW method of appendicular lean mass, hand grip strength (right & left), low hand grip strength (60 years and older) and usual walking pace on cirrhosis. CI, confidence interval; OR, odds ratio; SNP, single-nucleotide polymorphism; MR, Mendelian randomization; IVW, inverse-variance weighted.
See this image and copyright information in PMC

Comment on

  • Liver cirrhosis and sarcopenia: a dreadful combination.
    Kuchay MS, Martínez-Montoro JI, Llamoza-Torres CJ, Fernández-García JC, Ramos-Molina B. Kuchay MS, et al. Hepatobiliary Surg Nutr. 2022 Oct;11(5):729-731. doi: 10.21037/hbsn-22-355. Hepatobiliary Surg Nutr. 2022. PMID: 36268240 Free PMC article. No abstract available.

References

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    1. Kim G, Kang SH, Kim MY, et al. Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis. PLoS One 2017;12:e0186990. 10.1371/journal.pone.0186990 - DOI - PMC - PubMed
    1. Birney E. Mendelian Randomization. Cold Spring Harb Perspect Med 2022;12:a041302. - PMC - PubMed
    1. Pei YF, Liu YZ, Yang XL, et al. The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study. Commun Biol 2020;3:608. 10.1038/s42003-020-01334-0 - DOI - PMC - PubMed
    1. Emdin CA, Haas ME, Khera AV, et al. A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genet 2020;16:e1008629. 10.1371/journal.pgen.1008629 - DOI - PMC - PubMed