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Review
. 2023 Apr 14:14:1162554.
doi: 10.3389/fmicb.2023.1162554. eCollection 2023.

Pathophysiology and mechanisms of hearing impairment related to neonatal infection diseases

Daniela Capra  1   2   3 , Marcos F DosSantos  1   3   4   5 , Carolina K Sanz  5 , Lionete Gall Acosta Filha  1   3   5 , Priscila Nunes  2 , Manoela Heringer  2 , Adriana Ximenes-da-Silva  6 , Luciana Pessoa  2 , Juliana de Mattos Coelho-Aguiar  1   2   3   7 , Anna Carolina Carvalho da Fonseca  2 , Carmelita Bastos Mendes  6 , Lanni Sarmento da Rocha  6 , Sylvie Devalle  2 , Paulo Niemeyer Soares Filho  3 , Vivaldo Moura-Neto  1   2   3   7
Affiliations
Review

Pathophysiology and mechanisms of hearing impairment related to neonatal infection diseases

Daniela Capra et al. Front Microbiol. .

Abstract

The inner ear, the organ of equilibrium and hearing, has an extraordinarily complex and intricate arrangement. It contains highly specialized structures meticulously tailored to permit auditory processing. However, hearing also relies on both peripheral and central pathways responsible for the neuronal transmission of auditory information from the cochlea to the corresponding cortical regions. Understanding the anatomy and physiology of all components forming the auditory system is key to better comprehending the pathophysiology of each disease that causes hearing impairment. In this narrative review, the authors focus on the pathophysiology as well as on cellular and molecular mechanisms that lead to hearing loss in different neonatal infectious diseases. To accomplish this objective, the morphology and function of the main structures responsible for auditory processing and the immune response leading to hearing loss were explored. Altogether, this information permits the proper understanding of each infectious disease discussed.

Keywords: COVID-19; HIV; Rubeola; congenital Zika virus; cytomegalovirus; hearing loss; human induced pluripotent stem cells; toxoplasmosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

GRAPHICAL ABSTRACT
GRAPHICAL ABSTRACT
Graphical abstract explaining the correlation between ear anatomy, hearing loss, and virus infection diseases. (1) Virus effects on the peripheral auditory process and (2) Virus effects on the central auditory process.
See this image and copyright information in PMC

References

    1. Abbas L., Rivolta M. N. (2019). The use of animal models to study cell transplantation in neuropathic hearing loss. Hear. Res. 377, 72–87. doi: 10.1016/j.heares.2019.03.014, PMID: - DOI - PubMed
    1. Adams Waldorf K. M., Stencel-Baerenwald J. E., Kapur R. P., Studholme C., Boldenow E., Vornhagen J., et al. . (2016). Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat. Med. 22, 1256–1259. doi: 10.1038/nm.4193, PMID: - DOI - PMC - PubMed
    1. Adibi J. J., Marques E. T. A., Cartus A., Beigi R. H. (2016). Teratogenic effects of the Zika virus and the role of the placenta. Lancet 387, 1587–1590. doi: 10.1016/S0140-6736(16)00650-4, PMID: - DOI - PubMed
    1. Alenina N., Bader M. (2019). ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models. Neurochem. Res. 44, 1323–1329. doi: 10.1007/s11064-018-2679-4, PMID: - DOI - PMC - PubMed
    1. Almeida J. D., Tyrrell D. A. J. (1967). The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture. J. Gen. Virol. 1, 175–178. doi: 10.1099/0022-1317-1-2-175, PMID: - DOI - PubMed

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