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Editorial
. 2023 May 1;34(5):729-731.
doi: 10.1681/ASN.0000000000000110.

Genetic Association Analysis of Chronic Kidney Disease Progression in a Small Korean Cohort Study

Sahar Ghasemi  1 , Matthias Wuttke
Affiliations
Editorial

Genetic Association Analysis of Chronic Kidney Disease Progression in a Small Korean Cohort Study

Sahar Ghasemi et al. J Am Soc Nephrol. .
No abstract available

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Figures

Figure 1
Figure 1
Absolute change in annual eGFR decline detectable with 80% power by minor allele frequency. Colors represent three cohort sizes (n=2500/10,000/100,000). Power calculations assume a P value threshold of 5×10−8 and a SD for eGFR decline of 0.42 and were performed using the R package gwas-power (https://github.com/kaustubhad/gwas-power).
See this image and copyright information in PMC

Comment on

  • Novel Genetic Variants Associated with Chronic Kidney Disease Progression.
    Han M, Moon S, Lee S, Kim K, An WJ, Ryu H, Kang E, Ahn JH, Sung HY, Park YS, Lee SE, Lee SH, Jeong KH, Ahn C, Kelly TN, Hsu JY, Feldman HI, Park SK, Oh KH. Han M, et al. J Am Soc Nephrol. 2023 May 1;34(5):857-875. doi: 10.1681/ASN.0000000000000066. Epub 2023 Jan 5. J Am Soc Nephrol. 2023. PMID: 36720675 Free PMC article.

References

    1. GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England). 2020;395(10225):709–733. doi:10.1016/S0140-6736(20)30045-3 - DOI - PMC - PubMed
    1. KDIGO Conference Participants. Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney Int. 2022;101(6):1126–1141. doi:10.1016/j.kint.2022.03.019 - DOI - PMC - PubMed
    1. Shou H, Hsu JY, Xie D, et al. . Analytic considerations for repeated measures of eGFR in cohort studies of CKD. Clin J Am Soc Nephrol. 2017;12(8):1357–136510.2215/CJN.11311116 - DOI - PMC - PubMed
    1. Coresh J, Turin TC, Matsushita K, et al. . Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA. 2014;311(24):2518–2531. doi:10.1001/jama.2014.6634 - DOI - PMC - PubMed
    1. Franceschini N, Morris AP. Genetics of kidney traits in worldwide populations: the Continental Origins and Genetic Epidemiology Network (COGENT) Kidney Consortium. Kidney Int. 2020;98(1):35–41. doi:10.1016/j.kint.2020.02.036 - DOI - PMC - PubMed