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Case Reports
. 2023 Jan 27:44:56.
doi: 10.11604/pamj.2023.44.56.37632. eCollection 2023.

Primary malignant melanoma of prostate: a case report

Pirzada Faisal Masood  1 , Umesh Sharma  1 , Rajeev Sood  1 , Arvind Ahuja  2
Affiliations
Case Reports

Primary malignant melanoma of prostate: a case report

Pirzada Faisal Masood et al. Pan Afr Med J. .

Abstract

While primary genitourinary melanomas account for less than 1% of all melanoma cases, prostatic melanoma is extremely uncommon. These patients are challenging to identify, with a dismal prognosis. We reported a 52-year-old male patient who presented with lower urinary tract symptoms in the last one and a half months. The patient underwent Holmium laser enucleation of the prostate, and the histopathology result of the resected specimen showed prostatic melanoma. Investigations for systemic melanoma evaluation were negative, and the patient underwent radical cystoprostatectomy, urethrectomy, and bilateral lymph node dissection. The patient refused chemotherapy, developed lung metastasis shortly after surgery at three months, and succumbed to the metastatic disease with overall survival of 6 months. In conclusion, primary malignant melanoma of the prostate is a very rare disease. The most logical therapeutic strategy is aggressive surgical resection, followed immediately by adjuvant therapy.

Keywords: Melanoma; case report; metastasis; prostate.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
magnetic resonance imaging of the prostate showing - A) T2-weighted indicating lesion in the peripheral zone (white line); B) apparent diffusion coefficient (ADC) indicating focal mild to moderate hypointensity in the peripheral zone (white line)
Figure 2
Figure 2
cystoscopy photo of pigmented lesion (arrow)
Figure 3
Figure 3
A) enlarged blue-black pelvic lymph nodes (arrow); B) cystoprostatectomy with urethra specimen
Figure 4
Figure 4
histopathological photos showing - A) round nuclei tumor cells with prominent nucleoli and moderate cytoplasm, both intracellular and extracellular deposit of melanin pigment is seen [H&E,400X]; B) tumour cells with cytoplasmic positivity for HMB-45 [IHC,200X]
See this image and copyright information in PMC

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