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. 2023 Sep;25(9):2707-2717.
doi: 10.1007/s12094-023-03177-7. Epub 2023 May 2.

SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022)

César Serrano #  1 , Rosa Álvarez #  2 , Juan Antonio Carrasco #  3 , Gloria Marquina #  4 , Jerónimo Martínez-García #  5 , Virginia Martínez-Marín #  6 , María Ángeles Sala #  7 , Ana Sebio #  8 , Isabel Sevilla #  9 , Javier Martín-Broto #  10
Affiliations

SEOM-GEIS clinical guideline for gastrointestinal stromal tumors (2022)

César Serrano et al. Clin Transl Oncol. 2023 Sep.

Abstract

Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of mesenchymal origin, and a paradigmatic model for a successful rational development of targeted therapies in cancer. The introduction of tyrosine kinase inhibitors with activity against KIT/PDGFRA in both localized and advanced stages has remarkably improved the survival in a disease formerly deemed resistant to all systemic therapies. These guidelines are elaborated by the conjoint effort of the Spanish Society of Medical Oncology (SEOM) and the Spanish Sarcoma Research Group (GEIS) and provide a multidisciplinary and updated consensus for the diagnosis and treatment of GIST patients. We strongly encourage that the managing of these patients should be performed within multidisciplinary teams in reference centers.

Keywords: Avapritinib; GIST; Imatinib; Ripretinib.

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Conflict of interest statement

C.S. has received research funding (institution) from IDRX, Karyopharm, Pfizer, Deciphera, and Bayer AG; consulting fees (advisory role) from CogentBio, Immunicum AB, Deciphera Pharmaceuticals, and Blueprint Medicines; payment for lectures from Deciphera Pharmaceuticals, PharmaMar, Pfizer, Bayer AG, and Blueprint Medicines; and travel grants from PharmaMar, Gilead, Pfizer, and Bayer AG. R.A. reports personal honoraria, advisory fees, and travel expenses from Pharmamar, Roche, and Novartis outside the submitted work. Institutional research grants from Pharmamar, Roche, GSK, Cebiotex, RAIN Therapeutics, MSD, Eli Lilly, Boehringer, Astra Zeneca, Novartis, Sanofi, and Janssen. Remaining authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Algorithm for the management of localized disease
Fig. 2
Fig. 2
Algorithm for the management of metastatic disease
See this image and copyright information in PMC

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