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. 2023 May 2;18(5):e0285080.
doi: 10.1371/journal.pone.0285080. eCollection 2023.

Association between smoking behavior and serum uric acid among the adults: Findings from a national cross-sectional study

Yun Seo Jang  1   2 , Nataliya Nerobkova  1   2 , Il Yun  1   2 , Hyunkyu Kim  2   3 , Eun-Cheol Park  2   3
Affiliations

Association between smoking behavior and serum uric acid among the adults: Findings from a national cross-sectional study

Yun Seo Jang et al. PLoS One. .

Abstract

Background: Gout incidence is increasing worldwide; appropriate management of serum uric acid levels and a healthy lifestyle may help its prevention. The popularity of electronic cigarettes and the resultant emergence of dual smokers is increasing. Despite many studies on the effects of various health behaviors on serum uric acid levels, the association between smoking and serum uric acid levels remains controversial. This study aimed to investigate the association between smoking and serum uric acid levels.

Methods: In this study, total sample of 27,013 participants (11,924 men and 15,089 women) were analyzed. This study used data from the Korea National Health and Nutrition Examination Survey (2016-2020) and grouped adults into dual smokers, single smokers, ex-smokers, and non-smokers. Multiple logistic regression analyses were performed to investigate the association between smoking behavior and serum uric acid levels.

Results: Compared to male non-smokers, male dual smokers had significantly higher serum uric acid level (odds ratio [OR], 1.43; 95% confidence interval [CI], 1.08-1.88). In female, serum uric acid level was higher among single smokers than non-smokers (OR, 1.68; 95% CI, 1.25-2.25). Higher serum uric acid levels were more likely to be present in male dual smokers with a > 20 pack-year smoking habit (OR, 1.84; 95% CI, 1.06-3.18).

Conclusion: Dual smoking may contribute to high serum uric acid levels in adults. Thus, serum uric acid levels should be properly managed through smoking cessation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Results of subgroup analysis stratified by the smoking behavior and pack-year.
See this image and copyright information in PMC

References

    1. Engel B, Just J, Bleckwenn M, Weckbecker K. Treatment Options for Gout. Dtsch Arztebl Int. 2017;114: 215–222. doi: 10.3238/arztebl.2017.0215 - DOI - PMC - PubMed
    1. Rock KL, Kataoka H, Lai JJ. Uric acid as a danger signal in gout and its comorbidities. Nat Rev Rheumatol. 2013;9: 13–23. doi: 10.1038/nrrheum.2012.143 - DOI - PMC - PubMed
    1. Kuo CF, Grainge MJ, Zhang W, Doherty M. Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol. 2015;11: 649–662. doi: 10.1038/nrrheum.2015.91 - DOI - PubMed
    1. Singh JA, Edwards NL. Gout management and outcomes during the COVID-19 pandemic: a cross-sectional internet survey. Ther Adv Musculoskelet Dis. 2020;12: 1759720x20966124. doi: 10.1177/1759720X20966124 - DOI - PMC - PubMed
    1. Simeunovic Ostojic M, Maas J. Anorexia nervosa and uric acid beyond gout: An idea worth researching. Int J Eat Disord. 2018;51: 97–101. doi: 10.1002/eat.22817 - DOI - PubMed