Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 May;29(5):1064-1065.
doi: 10.1038/s41591-023-02322-7.

Unmasking the elusive erythropoietin-producing 'Norn' cell

Amin Abedini  1   2   3   4 , Konstantin A Klötzer  1   2   3   4   5 , Katalin Susztak  6   7   8   9
Affiliations
Comment

Unmasking the elusive erythropoietin-producing 'Norn' cell

Amin Abedini et al. Nat Med. 2023 May.

Abstract

Single-cell analyses in humans and mice have revealed the identity of the erythropoietin producing cells of the kidney — opening up new avenues of research for anemia and related disorders.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no competing financial interests.

Figures

Fig. 1 |
Fig. 1 |. The identification of erythropoietin-producing ‘Norn’ cells.
Hypoxia is sensed by hypoxia-inducible factor (HIF), which is the primary regulator of erythropoietin (EPO) production. EPO acts on erythroid progenitors to stimulate red blood cell production. Using an Epo-tagged kidney mouse model (in which EPO expression is linked to fluorescent protein) under hypoxic conditions and single-cell RNA sequencing, the research team identified a subpopulation of stromal cells, which they termed ‘Norn cells’, as the primary source of EPO in the kidney. Norn cells express Cxcl14, Col1a1, Dcn, Lpar1, Hsd11b1, Cxcl12 and Cfh and are enriched for a variety of transcription factors including TCF21, CEBPD, GATA6 and TSHZ2. Understanding these cells may reveal new therapeutic targets for combating anemia.
See this image and copyright information in PMC

Comment on

  • The transcriptional and regulatory identity of erythropoietin producing cells.
    Kragesteen BK, Giladi A, David E, Halevi S, Geirsdóttir L, Lempke OM, Li B, Bapst AM, Xie K, Katzenelenbogen Y, Dahl SL, Sheban F, Gurevich-Shapiro A, Zada M, Phan TS, Avellino R, Wang SY, Barboy O, Shlomi-Loubaton S, Winning S, Markwerth PP, Dekalo S, Keren-Shaul H, Kedmi M, Sikora M, Fandrey J, Korneliussen TS, Prchal JT, Rosenzweig B, Yutkin V, Racimo F, Willerslev E, Gur C, Wenger RH, Amit I. Kragesteen BK, et al. Nat Med. 2023 May;29(5):1191-1200. doi: 10.1038/s41591-023-02314-7. Epub 2023 Apr 27. Nat Med. 2023. PMID: 37106166

References

    1. Jelkmann W Respir. Physiol 63, 257–266 (1986). - PubMed
    1. Wojchowski D Nature 470, 40–40 (2011). - PubMed
    1. Kragesteen AG et al. Nat. Med 10.1038/s41591-023-02314-7 (2023). - DOI
    1. Semenza GL Annu. Rev. Med 74, 307–319 (2023). - PubMed
    1. KDIGO. Kidney Int Suppl. 2, 283–287 (2012).

MeSH terms

LinkOut - more resources