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[Preprint]. 2023 Feb 26:2023.02.23.23286373.
doi: 10.1101/2023.02.23.23286373.

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

James J Crowley  1   2 , Carolina Cappi  3   4 , Marcos E Ochoa-Panaifo  5 , Renee M Frederick  6 , Minjee Kook  6 , Andrew D Wiese  6 , Diana Rancourt  7 , Elizabeth G Atkinson  8 , Paola Giusti-Rodriguez  9 , Jacey L Anderberg  6 ; Latin American Trans-ancestry INitiative for OCD genomics (LATINO), Brazilian Obsessive-Compulsive Spectrum Disorder Working Group (GTTOC); Jonathan S Abramowitz  10 , Victor R Adorno  11 , Cinthia Aguirre  12 , Gustavo S Alves  13   14 , Gilberto S Alves  15 , NaEshia Ancalade  1 , Alejandro A Arellano Espinosa  16 , Paul D Arnold  17 , Daphne M Ayton  6 , Izabela G Barbosa  18 , Laura Marcela Barón Castano  19 , Cynthia N Barrera  20 , María Belén Prieto  21 , María Celeste Berardo  21 , Dayan Berrones  22 , John R Best  23 , Tim B Bigdeli  24   25 , Christie L Burton  26 , Jennifer L Callahan  27 , Maria Cecília B Carneiro  28 , Sandra L Cepeda  29 , Evelyn Chazelle  21 , Jessica M Chire  30 , Macarena Churruca Munoz  31 , Pamela Claisse Quiroz  32 , Journa Cobite  33 , Jonathan S Comer  34 , Daniel L Costa  4 , Jennifer Crosbie  26   35 , Victor O Cruz  36   37 , Guillermo Dager  38 , Luisa F Daza  19 , Anabel de la Rosa-Gómez  39 , Daniela Del Río  40 , Fernanda Z Delage  41 , Carolina B Dreher  42   43 , Lucila Fay  21 , Tomas Fazio  21 , Ygor A Ferrão  44 , Gabriela M Ferreira  41   45 , Edith G Figueroa  46 , Leonardo F Fontenelle  47   48 , Diego A Forero  49 , Daniele Th Fragoso  41 , Bharathi S Gadad  50 , Sheldon R Garrison  51 , Andres González  52 , Laura D Gonzalez  21 , Marco A González  39 , Polaris Gonzalez-Barrios  53   54 , Wayne Goodman  6 , Jerry Guintivano  2 , Daniel G Guttfreund  55 , Andrew G Guzick  6 , Matthew W Halvorsen  1 , Joseph D Hovey  56 , Reinhard Janssen-Aguilar  57 , Matias Jensen  58 , Alexandra Z Jimenez Reynolds  6 , Joali Alexandra Juárez Lujambio  59 , Nasim Khalfe  60 , Madison A Knutsen  61   6 , Caleb Lack  62 , Nuria Lanzagorta  63 , Monicke O Lima  4 , Melanie O Longhurst  50 , David A Lozada Martinez  5 , Elba S Luna  36 , Andrea H Marques  64 , Molly Martinez  65   66 , Maria de Los Angeles Matos  21 , Caitlyn E Maye  6 , Joseph F McGuire  67 , Gabriela Menezes  68 , Charlene Minaya  69 , Tomás Miño  58 , Sara M Mithani  70 , Circe Montes de Oca  71 , Alonso Morales-Rivero  72 , Maria E Moreira-de-Oliveira  68 , Olivia J Morris  6 , Sandra I Muñoz  39 , Zainab Naqqash  23 , Ambar A Núñez Bracho  52 , Belinda E Núñez Bracho  52 , Maria Corina Ochoa Rojas  19 , Luis A Olavarria Castaman  5 , Iliana Ortega  17 , Darpan I Patel  70 , Ainsley K Patrick  67 , Mariel Paz Y Mino  73   74 , Jose L Perales Orellana  75 , Bárbara Perdigão Stumpf  18 , Tamara Peregrina  71 , Tania Pérez Duarte  20 , Kelly L Piacsek  51 , Maritza Placencia  76 , Lucas C Quarantini  77   13 , Yana Quarantini-Alvim  13   78 , Renato T Ramos  79   35 , Iaroslava C Ramos  79   80 , Vanessa R Ramos  4 , Kesley A Ramsey  67 , Elise V Ray  1 , Margaret A Richter  79   81 , Bradley C Riemann  51 , Juan C Rivas  19   82   83   84 , Maria C Rosario  85 , Camilo J Ruggero  27 , Angel A Ruiz-Chow  72 , Alejandra Ruiz-Velasco  50 , Aline S Sampaio  77   14   13 , Leonardo C Saraiva  4 , Russell J Schachar  26   35 , Sophie C Schneider  6 , Ethan J Schweissing  6 , Laura D Seligman  56 , Roseli G Shavitt  4 , Keaton J Soileau  6 , S Evelyn Stewart  23   86   87 , Shaina B Storch  88 , Emily R Strouphauer  60 , Kiara R Timpano  29 , Beatriz Treviño-de la Garza  89 , Javier Vargas-Medrano  50 , María I Vásquez  90 , Guadalupe Vidal Martinez  50 , Saira A Weinzimmer  6 , Mauricio A Yanez  6 , Gwyneth Zai  91   81 , Lina M Zapata-Restrepo  92   93   94 , Luz M Zappa  21   95   96 , Raquel M Zepeda-Burgos  97 , Anthony W Zoghbi  6   98 , Euripedes C Miguel  4 , Carolyn I Rodriguez  99   100 , Mayra C Martinez Mallen  72 , Pablo R Moya  31   101 , Tania Borda  102   103 , María Beatriz Moyano  21   104   105 , Manuel Mattheisen  106   107 , Stacey Pereira  108 , Gabriel Lázaro-Muñoz  109   110 , Karen G Martinez-Gonzalez  53 , Michele T Pato  111 , Humberto Nicolini  112   113 , Eric A Storch  6
Affiliations

Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study Protocol

James J Crowley et al. medRxiv. .

Update in

  • Latin American Trans-ancestry INitiative for OCD genomics (LATINO): Study protocol.
    Crowley JJ, Cappi C, Ochoa-Panaifo ME, Frederick RM, Kook M, Wiese AD, Rancourt D, Atkinson EG, Giusti-Rodriguez P, Anderberg JL; Latin American Trans‐ancestry INitiative for OCD genomics; Brazilian Obsessive‐Compulsive Spectrum Disorder Working Group; Abramowitz JS, Adorno VR, Aguirre C, Alves GS, Alves GS, Ancalade N, Arellano Espinosa AA, Arnold PD, Ayton DM, Barbosa IG, Castano LMB, Barrera CN, Berardo MC, Berrones D, Best JR, Bigdeli TB, Burton CL, Buxbaum JD, Callahan JL, Carneiro MCB, Cepeda SL, Chazelle E, Chire JM, Munoz MC, Quiroz PC, Cobite J, Comer JS, Costa DL, Crosbie J, Cruz VO, Dager G, Daza LF, de la Rosa-Gómez A, Del Río D, Delage FZ, Dreher CB, Fay L, Fazio T, Ferrão YA, Ferreira GM, Figueroa EG, Fontenelle LF, Forero DA, Fragoso DTH, Gadad BS, Garrison SR, González A, Gonzalez LD, González MA, Gonzalez-Barrios P, Goodman WK, Grice DE, Guintivano J, Guttfreund DG, Guzick AG, Halvorsen MW, Hovey JD, Huang H, Irreño-Sotomonte J, Janssen-Aguilar R, Jensen M, Jimenez Reynolds AZ, Lujambio JAJ, Khalfe N, Knutsen MA, Lack C, Lanzagorta N, Lima MO, Longhurst MO, Lozada Martinez DA, Luna ES, Marques AH, Martinez MS, de Los Angeles Matos M, Maye CE, McGuire JF, Menezes G… See abstract for full author list ➔ Crowley JJ, et al. Am J Med Genet B Neuropsychiatr Genet. 2024 Jun;195(4):e32962. doi: 10.1002/ajmg.b.32962. Epub 2023 Nov 9. Am J Med Genet B Neuropsychiatr Genet. 2024. PMID: 37946624 Free PMC article.

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long-sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans-ancestry INitiative for OCD genomics (LATINO, www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5,000 richly-phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans-ancestry genomic analyses to accelerate the identification of OCD risk loci, fine-map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

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Figures

Figure 1
Figure 1
LATINO study sites.
See this image and copyright information in PMC

References

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