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. 2023 Aug;39(8):2139-2146.
doi: 10.1007/s00381-023-05927-y. Epub 2023 May 3.

Frontal sinus hypoplasia in unoperated older patients with craniosynostosis: a pilot study

Sonia K Pandey  1 , Christopher L Kalmar  2 , Christopher M Bonfield  3 , Michael S Golinko  1
Affiliations

Frontal sinus hypoplasia in unoperated older patients with craniosynostosis: a pilot study

Sonia K Pandey et al. Childs Nerv Syst. 2023 Aug.

Abstract

Purpose: The purpose of this study is to determine whether patients with unoperated craniosynostosis have different frontal sinus pneumatization than unaffected controls.

Methods: Retrospective review was performed between 2009 and 2020 of previously unoperated patients with craniosynostosis older than 5 years old at first presentation to our institution. Total frontal sinus volume (FSV) was calculated using 3D volume rendering tool in Sectra IDS7 PACS system. Age-matched normative FSV data was collected from 100 normal CT scans for the control group. The two groups were statistically compared using Fisher's exact test and T-test.

Results: Study group included nine patients, 5-39 years old, median age 7 years. Frontal sinus pneumatization was absent in 12% of the normal 7-year-old controls, while frontal sinus pneumatization was absent in 89% of the studied craniosynostosis patients (p < .001). Mean FSV of the study group (113 ± 340 mm3) was significantly different from that of age matched control mean FSV (2016 ± 2529 mm3) (p = .027).

Conclusions: Frontal sinus pneumatization is suppressed in unreleased craniosynostosis and may be an intracranial space conservation phenomenon. This absent frontal sinus can have implications in future frontal region trauma and frontal osteotomies.

Keywords: Cranial vault remodeling; Craniosynostosis; Frontal sinus hypoplasia.

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References

    1. Pfefferbaum A, Mathalon DH, Sullivan EV et al (1994) A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 51:874–887. https://doi.org/10.1001/ARCHNEUR.1994.00540210046012 - DOI - PubMed
    1. Frič R, Langvatn EA, Due-Tønnessen BJ, Eide PK (2021) The role of pulsatile and static intracranial pressure measurements in the management of children with craniosynostosis-an institutional experience from 49 patients. Acta Neurochir (Wien) 163:2015–2023. https://doi.org/10.1007/S00701-020-04680-4 - DOI - PubMed
    1. Hayward R, Gonsalez S (2005) How low can you go? Intracranial pressure, cerebral perfusion pressure, and respiratory obstruction in children with complex craniosynostosis. J Neurosurg 102:16–22. https://doi.org/10.3171/PED.2005.102.1.0016 - DOI - PubMed
    1. Fok H, Jones BM, Gault DG et al (1992) Relationship between intracranial pressure and intracranial volume in craniosynostosis. Br J Plast Surg 45:394–397. https://doi.org/10.1016/0007-1226(92)90013-N - DOI - PubMed
    1. Hayreh SS (2016) Pathogenesis of optic disc edema in raised intracranial pressure. Prog Retin Eye Res 50:108–144. https://doi.org/10.1016/J.PRETEYERES.2015.10.001 - DOI - PubMed - PMC

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