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Comment
. 2023 May 2;35(5):728-729.
doi: 10.1016/j.cmet.2023.04.004.

Neurotransmitters arrive to control systemic autoimmunity

Marc Scherlinger  1 , George C Tsokos  2
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Neurotransmitters arrive to control systemic autoimmunity

Marc Scherlinger et al. Cell Metab. .
Free article

Abstract

Immune cell microenvironment plays a major role in the aberrant function of immune cells in systemic lupus erythematosus. Zeng and co-authors show that in human and murine lupus, splenic stromal cell-derived acetylcholine switches B cell metabolism to fatty acid oxidation and promotes B cell autoreactivity and disease development.

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Declaration of interests The authors declare no competing interests.

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